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Crabtree JS, Singleton CS, Miele L. Notch Signaling in Neuroendocrine Tumors. Front Oncol. 2016;6:94doi: 10.3389/fonc.2016.00094.
Crabtree, J. S., Singleton, C. S., & Miele, L. (2016). Notch Signaling in Neuroendocrine Tumors. Frontiers in oncology, 694. https://doi.org/10.3389/fonc.2016.00094
Crabtree, Judy S, et al. "Notch Signaling in Neuroendocrine Tumors." Frontiers in oncology vol. 6 (2016): 94. doi: https://doi.org/10.3389/fonc.2016.00094
Crabtree JS, Singleton CS, Miele L. Notch Signaling in Neuroendocrine Tumors. Front Oncol. 2016 Apr 14;6:94. doi: 10.3389/fonc.2016.00094. eCollection 2016. PMID: 27148486; PMCID: PMC4830836.
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Front Oncol. 2016 Apr 14;6:94. doi: 10.3389/fonc.2016.00094. eCollection 2016.

Notch Signaling in Neuroendocrine Tumors.

Frontiers in oncology

Judy S Crabtree, Ciera S Singleton, Lucio Miele

Affiliations

  1. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
  2. Department of Genetics, Louisiana State University Health Sciences Center , New Orleans, LA , USA.

PMID: 27148486 PMCID: PMC4830836 DOI: 10.3389/fonc.2016.00094

Abstract

Carcinoids and neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise from the neuroendocrine cells of the GI tract, endocrine pancreas, and the respiratory system. NETs remain significantly understudied with respect to molecular mechanisms of pathogenesis, particularly the role of cell fate signaling systems such as Notch. The abundance of literature on the Notch pathway is a testament to its complexity in different cellular environments. Notch receptors can function as oncogenes in some contexts and tumor suppressors in others. The genetic heterogeneity of NETs suggests that to fully understand the roles and the potential therapeutic implications of Notch signaling in NETs, a comprehensive analysis of Notch expression patterns and potential roles across all NET subtypes is required.

Keywords: Notch; SCLC; carcinoid; neuroendocrine tumors; pNET; small-cell lung cancer

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