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Borda LJ, Wikramanayake TC. Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J Clin Investig Dermatol. 2015;3(2)doi: 10.13188/2373-1044.1000019.
Borda, L. J., & Wikramanayake, T. C. (2015). Seborrheic Dermatitis and Dandruff: A Comprehensive Review. Journal of clinical and investigative dermatology, 3(2), . https://doi.org/10.13188/2373-1044.1000019
Borda, Luis J, and Wikramanayake, Tongyu C. "Seborrheic Dermatitis and Dandruff: A Comprehensive Review." Journal of clinical and investigative dermatology vol. 3,2 (2015). doi: https://doi.org/10.13188/2373-1044.1000019
Borda LJ, Wikramanayake TC. Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J Clin Investig Dermatol. 2015 Dec;3(2). doi: 10.13188/2373-1044.1000019. Epub 2015 Dec 15. PMID: 27148560; PMCID: PMC4852869.
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J Clin Investig Dermatol. 2015 Dec;3(2). doi: 10.13188/2373-1044.1000019. Epub 2015 Dec 15.

Seborrheic Dermatitis and Dandruff: A Comprehensive Review.

Journal of clinical and investigative dermatology

Luis J Borda, Tongyu C Wikramanayake

Affiliations

  1. Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 2023A, Miami, Florida 33136, USA.

PMID: 27148560 PMCID: PMC4852869 DOI: 10.13188/2373-1044.1000019

Abstract

Seborrheic Dermatitis (SD) and dandruff are of a continuous spectrum of the same disease that affects the seborrheic areas of the body. Dandruff is restricted to the scalp, and involves itchy, flaking skin without visible inflammation. SD can affect the scalp as well as other seborrheic areas, and involves itchy and flaking or scaling skin, inflammation and pruritus. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors, all contribute to the pathogenesis of SD and dandruff. In this review, we summarize the current knowledge on SD and dandruff, including epidemiology, burden of disease, clinical presentations and diagnosis, treatment, genetic studies in humans and animal models, and predisposing factors. Genetic and biochemical studies and investigations in animal models provide further insight on the pathophysiology and strategies for better treatment.

Keywords: Dandruff; Epidermal barrier; Malassezia; Sebaceous gland; Seborrheic dermatitis

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