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Han R, Lu H, Jiang MW, et al. Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterol Res Pract. 2016;2016:8547686doi: 10.1155/2016/8547686.
Han, R., Lu, H., Jiang, M. W., Tan, K. W., Peng, Z., Hu, J. L., Fang, D. C., Lan, C. H., & Wu, X. L. (2016). Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterology research and practice, 20168547686. https://doi.org/10.1155/2016/8547686
Han, Ran, et al. "Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China." Gastroenterology research and practice vol. 2016 (2016): 8547686. doi: https://doi.org/10.1155/2016/8547686
Han R, Lu H, Jiang MW, Tan KW, Peng Z, Hu JL, Fang DC, Lan CH, Wu XL. Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterol Res Pract. 2016;2016:8547686. doi: 10.1155/2016/8547686. Epub 2016 May 09. PMID: 27247569; PMCID: PMC4876203.
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Gastroenterol Res Pract. 2016;2016:8547686. doi: 10.1155/2016/8547686. Epub 2016 May 09.

Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China.

Gastroenterology research and practice

Ran Han, Hong Lu, Ming-Wan Jiang, Ke-Wen Tan, Zhong Peng, Jia-Li Hu, Dian-Chun Fang, Chun-Hui Lan, Xiao-Ling Wu

Affiliations

  1. The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  2. Department of Gastroenterology, Changshou District People's Hospital, Chongqing 400016, China.
  3. Department of Gastroenterology, Sanxia Central Hospital, Chongqing 400016, China.
  4. Department of Gastroenterology, Dianjiang County People's Hospital, Chongqing 400016, China.
  5. Department of Gastroenterology, Qijiang County People's Hospital, Chongqing 400016, China.
  6. Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400016, China.
  7. Department of Gastroenterology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

PMID: 27247569 PMCID: PMC4876203 DOI: 10.1155/2016/8547686

Abstract

This study was to investigate the antibiotic resistance profile of H. pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China. 214 and 111 strains of H. pylori were isolated from rural and urban patients, respectively. 99.53%, 20.09%, and 23.36% of the isolates in rural patients were found to be resistant to metronidazole, clarithromycin, and levofloxacin, while the resistant rate in urban patients was 82.88%, 19.82%, and 24.32%. The multiple antibiotic resistance percentage significantly increased from 28.26% (below 45 years) to 41.80% (above 45 years) in rural patients. Up to 44.39%, 45.79%, and 9.81% of rural patients from whom H. pylori was isolated were found to be extensive metabolizers, intermediate metabolizers, and poor metabolizers. No correlation was observed between antibiotic resistance profile of H. pylori and genetic polymorphism of CYP2C19 among rural population. There was a high prevalence of H. pylori strains resistant to metronidazole, clarithromycin, and levofloxacin in rural patients in Chongqing, China. The choice of therapy in this area should be based on local susceptibility patterns. Amoxicillin, gentamicin, and furazolidone are recommended as the first-line empiric regimen.

References

  1. Lancet Oncol. 2012 Jun;13(6):607-15 - PubMed
  2. J Antimicrob Chemother. 1997 Jan;39(1):5-12 - PubMed
  3. Am J Gastroenterol. 1999 Sep;94(9):2373-9 - PubMed
  4. Cancer Res. 2008 May 1;68(9):3540-8 - PubMed
  5. World J Gastroenterol. 2014 Aug 7;20(29):9898-911 - PubMed
  6. Clin Microbiol Rev. 2010 Oct;23(4):713-39 - PubMed
  7. World J Gastroenterol. 2014 Aug 14;20(30):10338-47 - PubMed
  8. Intern Emerg Med. 2012 Oct;7(5):447-52 - PubMed
  9. Clin Pharmacokinet. 1995 Sep;29(3):192-209 - PubMed
  10. Gut. 2012 May;61(5):646-64 - PubMed
  11. BMJ. 2014 May 20;348:g3174 - PubMed
  12. Helicobacter. 2014 Sep;19 Suppl 1:27-31 - PubMed
  13. Clin Pharmacokinet. 2002;41(12 ):913-58 - PubMed
  14. Clin Pharmacol Ther. 1996 Jun;59(6):647-53 - PubMed
  15. Helicobacter. 2004;9 Suppl 1:67-72 - PubMed
  16. Gut. 2010 Aug;59(8):1143-53 - PubMed
  17. J Gastrointestin Liver Dis. 2010 Dec;19(4):409-14 - PubMed
  18. Zhonghua Er Ke Za Zhi. 2004 Oct;42(10):769-71 - PubMed
  19. Turk J Pediatr. 2003 Apr-Jun;45(2):114-22 - PubMed
  20. J Res Med Sci. 2013 Dec;18(12):1056-60 - PubMed
  21. Aliment Pharmacol Ther. 2000 Oct;14 (10 ):1259-66 - PubMed
  22. N Engl J Med. 2001 Sep 13;345(11):784-9 - PubMed
  23. World J Gastroenterol. 2014 Oct 28;20(40):14973-85 - PubMed
  24. Annu Rev Pharmacol Toxicol. 2005;45:477-94 - PubMed
  25. J Microbiol. 2006 Aug;44(4):409-16 - PubMed
  26. World J Gastroenterol. 2015 Mar 7;21(9):2786-92 - PubMed
  27. J Biol Chem. 1994 Jun 3;269(22):15419-22 - PubMed
  28. Int J Antimicrob Agents. 2011 Jan;37(1):22-5 - PubMed

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