Iran J Child Neurol. 2016;10(2):16-25.
Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents.
Iranian journal of child neurology
Elham Fallah, Sorror Arman, Mostafa Najafi, Bahar Shayegh
Affiliations
Affiliations
- Child Psychiatry Department, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
- Child Psychiatrist, Isfahan university of medical sciences, Isfahan, Iran.
- Department of Psychology, Islamic Azad University, Sharekord Branch, Sharekord, Iran.
PMID: 27247580
PMCID: PMC4885151
Abstract
OBJECTIVE: Many studies have supported the role of protein kinase C (PKC) inhibitors in the physiopathology and treatment of bipolar disorder in adults. Tamoxifen is one of the drugs with the effect of PKC inhibition. This study aimed to determine the effect of tamoxifen on the rate of improvement mania symptoms in the sample of children and adolescents with acute mania.
MATERIALS & METHODS: In this randomized, placebo-controlled clinical trial study, registered in www.irct.ir with the code of IRCT201410126418N3, overall 44 patients with bipolar disorder with acute manic episode were randomly assigned into treatment and control groups. The serum levels of lithium and tamoxifen among the participants in the treatment groups were 0.8 -1.1 mg and 20-40 mg per day respectively. Serum level of lithium among participants in the control group was similar. The main comparisons were made based on the Young Mania Rating Scale (YMRS) and Children Depression Inventory (CDI) scores of the participants at baseline and at the end of each study week. The pharmacological side effects of serum level of lithium were examined weekly. Analysis of Covariance(ANCOVA) test was used for the statistical analysis.
RESULTS: There was no difference in the baseline score of YMRS and CDI in the treatment and control groups while a statistical significant difference (P < 0.05) in these scores was found between and within the groups.
CONCLUSION: The addition of tamoxifen to lithium causes a significant difference in reducing the symptoms of mania and depression in the treatment group compared to the control group.
Keywords: Children; Lithium; Mania; Protein Kinase C; Tamoxifen
References
- Arch Gen Psychiatry. 2000 Jan;57(1):95-7 - PubMed
- BMC Psychiatry. 2006 Mar 15;6:10 - PubMed
- Neuropsychobiology. 2007;55(3-4):123-31 - PubMed
- J Pediatr Hematol Oncol. 2000 May-Jun;22(3):247-51 - PubMed
- Biol Psychiatry. 1993 Apr 1;33(7):520-5 - PubMed
- Acta Psychiatr Scand Suppl. 2007;(434):27-34 - PubMed
- Biol Psychiatry. 1999 Nov 15;46(10):1328-51 - PubMed
- J Pediatr. 2003 Jul;143(1):60-6 - PubMed
- Bipolar Disord. 2007 Sep;9(6):561-70 - PubMed
- Psychoneuroendocrinology. 2006 May;31(4):543-7 - PubMed
- Psychosomatics. 2007 May-Jun;48(3):205-10 - PubMed
- Neurosci Biobehav Rev. 2007;31(6):825-31 - PubMed
- J Clin Psychiatry. 1999;60 Suppl 2:27-39; discussion 40-1, 113-6 - PubMed
- J Pediatr. 2004 Jul;145(1):71-6 - PubMed
- Biol Psychiatry. 1996 Oct 1;40(7):568-75 - PubMed
- Neuropharmacology. 1992 Dec;31(12):1201-10 - PubMed
- Curr Psychiatry Rep. 2007 Dec;9(6):521-8 - PubMed
- Psychopharmacology (Berl). 2007 Mar;191(1):39-54 - PubMed
- J Am Acad Child Adolesc Psychiatry. 2005 Jun;44(6):539-47 - PubMed
- J Psychopharmacol. 2009 May;23(3):334-7 - PubMed
- J Cell Biol. 2005 Sep 26;170(7):1147-58 - PubMed
- J Affect Disord. 2003 Nov;77(2):179-90 - PubMed
- Neuron. 2005 Oct 6;48(1):77-90 - PubMed
- Arch Gen Psychiatry. 2008 Mar;65(3):255-63 - PubMed
- Neuropharmacology. 1992 Dec;31(12):1211-22 - PubMed
- Mol Psychiatry. 2002;7 Suppl 1:S1-7 - PubMed
- Brain Res Mol Brain Res. 1993 Dec;20(4):289-98 - PubMed
- J Affect Disord. 2011 Mar;129(1-3):327-31 - PubMed
- Breast Cancer Res Treat. 1994;31(1):41-52 - PubMed
Publication Types