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Baek JH, Kim HJ, Fava M, et al. Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder. Psychiatry Investig. 2016;13(3):321-6doi: 10.4306/pi.2016.13.3.321.
Baek, J. H., Kim, H. J., Fava, M., Mischoulon, D., Papakostas, G. I., Nierenberg, A., Heo, J. Y., & Jeon, H. J. (2016). Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder. Psychiatry investigation, 13(3), 321-6. https://doi.org/10.4306/pi.2016.13.3.321
Baek, Ji Hyun, et al. "Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder." Psychiatry investigation vol. 13,3 (2016): 321-6. doi: https://doi.org/10.4306/pi.2016.13.3.321
Baek JH, Kim HJ, Fava M, Mischoulon D, Papakostas GI, Nierenberg A, Heo JY, Jeon HJ. Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder. Psychiatry Investig. 2016 May;13(3):321-6. doi: 10.4306/pi.2016.13.3.321. Epub 2016 May 18. PMID: 27247599; PMCID: PMC4878967.
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Psychiatry Investig. 2016 May;13(3):321-6. doi: 10.4306/pi.2016.13.3.321. Epub 2016 May 18.

Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder.

Psychiatry investigation

Ji Hyun Baek, Hee-Jin Kim, Maurizio Fava, David Mischoulon, George I Papakostas, Andrew Nierenberg, Jung-Yoon Heo, Hong Jin Jeon

Affiliations

  1. Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
  2. Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  3. Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
  4. Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.; Departments of Health Sciences & Technology, Management & Research, Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul, Republic of Korea.
  5. Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  6. Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.; Departments of Health Sciences & Technology, Management & Research, Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul, Republic of Korea.

PMID: 27247599 PMCID: PMC4878967 DOI: 10.4306/pi.2016.13.3.321

Abstract

OBJECTIVE: Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to characterize the role of inflammation on a development of anxious depression, we aimed to determine the relationship between white blood cell (WBC) subset counts and anxiety in individuals with major depressive disorder (MDD).

METHODS: A total of 709 patients who were newly diagnosed with MDD were recruited. Anxiety levels of participants were evaluated using the Anxiety/ Somatization subitem of the Hamilton Depression Rating Scale. The association between WBC subset fraction and anxiety was evaluated.

RESULTS: Basophil and eosinophil sub-fractions showed significant negative correlations with HAM-D anxiety/somatization factor scores (basophils: r=-0.092, p=0.014 and eosinophils: r=-0.075, p=0.046). When an anxiety score (a sum of somatic and psychic anxiety) was entered as a dependent variable, only basophils showed significant negative association with the anxiety scores after adjusting for all other WBC subset counts and demographic factors (t=-2.57, p=0.010).

CONCLUSION: This study showed that anxious depression had a decreased basophil subfraction, which might be associated with involvement of inflammation in development of anxious depression.

Keywords: Anxious depression; Basophil; Inflammation

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