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Girodet PO, Nguyen D, Mancini JD, et al. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016;55(4):467-475doi: 10.1165/rcmb.2015-0295OC.
Girodet, P. O., Nguyen, D., Mancini, J. D., Hundal, M., Zhou, X., Israel, E., & Cernadas, M. (2016). Alternative Macrophage Activation Is Increased in Asthma. American journal of respiratory cell and molecular biology, 55(4), 467-475. https://doi.org/10.1165/rcmb.2015-0295OC
Girodet, Pierre-Olivier, et al. "Alternative Macrophage Activation Is Increased in Asthma." American journal of respiratory cell and molecular biology vol. 55,4 (2016): 467-475. doi: https://doi.org/10.1165/rcmb.2015-0295OC
Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016 Oct;55(4):467-475. doi: 10.1165/rcmb.2015-0295OC. PMID: 27248771; PMCID: PMC5070104.
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Am J Respir Cell Mol Biol. 2016 Oct;55(4):467-475. doi: 10.1165/rcmb.2015-0295OC.

Alternative Macrophage Activation Is Increased in Asthma.

American journal of respiratory cell and molecular biology

Pierre-Olivier Girodet, Daniel Nguyen, John Dominic Mancini, Mandeep Hundal, Xiaobo Zhou, Elliot Israel, Manuela Cernadas

Affiliations

  1. 1 Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
  2. 2 University Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Département de Pharmacologie, Bordeaux, France; and.
  3. 3 Channing Division of Network Medicine, Harvard Medical School, Boston, Massachusetts.

PMID: 27248771 PMCID: PMC5070104 DOI: 10.1165/rcmb.2015-0295OC

Abstract

The immune responses of type 2 T helper cells (Th2) play an important role in asthma and promote the differentiation of alternatively activated (M2) macrophages. M2 macrophages have been increasingly understood to contribute to Th2 immunity. We hypothesized that M2 macrophages are altered in asthma and modulate Th2 responses. The aim of this study was to characterize the phenotype and function of human monocyte-derived M2 and bronchoalveolar lavage fluid (BALF) macrophages from healthy control subjects and subjects with asthma. Phenotypic characteristics and effector function of M2 macrophages were examined using monocyte-derived and BALF macrophages obtained from subjects with asthma (n = 28) and healthy volunteers (n = 9) by flow cytometry and quantitative PCR. Resting monocyte-derived (M0) and M2 macrophages were generated by the addition of macrophage colony-stimulating factor or macrophage colony-stimulating factor plus IL-4, respectively. M2 macrophage cytokine expression and their impact on dendritic and CD4

Keywords: alternatively activated macrophages; asthma; histamine receptor; major histocompatibility complex class II; mannose receptor

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