Display options
Cite
Herold IH, Saporito S, Mischi M, et al. Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony. Echo Res Pract. 2016;3(2):35-43doi: 10.1530/ERP-16-0011.
Herold, I. H., Saporito, S., Mischi, M., van Assen, H. C., Bouwman, R. A., de Lepper, A. G., van den Bosch, H. C., Korsten, H. H., & Houthuizen, P. (2016). Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony. Echo research and practice, 3(2), 35-43. https://doi.org/10.1530/ERP-16-0011
Herold, Ingeborg H F, et al. "Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony." Echo research and practice vol. 3,2 (2016): 35-43. doi: https://doi.org/10.1530/ERP-16-0011
Herold IH, Saporito S, Mischi M, van Assen HC, Bouwman RA, de Lepper AG, van den Bosch HC, Korsten HH, Houthuizen P. Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony. Echo Res Pract. 2016 Jun;3(2):35-43. doi: 10.1530/ERP-16-0011. Epub 2016 May 16. PMID: 27249553; PMCID: PMC4989099.
Copy Download .nbib Format: NLM
Share it on

Echo Res Pract. 2016 Jun;3(2):35-43. doi: 10.1530/ERP-16-0011. Epub 2016 May 16.

Pulmonary transit time measurement by contrast-enhanced ultrasound in left ventricular dyssynchrony.

Echo research and practice

Ingeborg H F Herold, Salvatore Saporito, Massimo Mischi, Hans C van Assen, R Arthur Bouwman, Anouk G W de Lepper, Harrie C M van den Bosch, Hendrikus H M Korsten, Patrick Houthuizen

Affiliations

  1. Department of Anesthesiology and Intensive-Care, Catharina Hospital Eindhoven, Eindhoven, the Netherlands [email protected].
  2. Department of Electrical Engineering, Signal Processing Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
  3. Department of Anesthesiology and Intensive-Care, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
  4. Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
  5. Department of Radiology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
  6. Department of Anesthesiology and Intensive-Care, Catharina Hospital Eindhoven, Eindhoven, the Netherlands Department of Electrical Engineering, Signal Processing Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.

PMID: 27249553 PMCID: PMC4989099 DOI: 10.1530/ERP-16-0011

Abstract

BACKGROUND: Pulmonary transit time (PTT) is an indirect measure of preload and left ventricular function, which can be estimated using the indicator dilution theory by contrast-enhanced ultrasound (CEUS). In this study, we first assessed the accuracy of PTT-CEUS by comparing it with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Secondly, we tested the hypothesis that PTT-CEUS correlates with the severity of heart failure, assessed by MRI and N-terminal pro-B-type natriuretic peptide (NT-proBNP).

METHODS AND RESULTS: Twenty patients referred to our hospital for cardiac resynchronization therapy (CRT) were enrolled. DCE-MRI, CEUS, and NT-proBNP measurements were performed within an hour. Mean transit time (MTT) was obtained by estimating the time evolution of indicator concentration within regions of interest drawn in the right and left ventricles in video loops of DCE-MRI and CEUS. PTT was estimated as the difference of the left and right ventricular MTT. Normalized PTT (nPTT) was obtained by multiplication of PTT with the heart rate. Mean PTT-CEUS was 10.5±2.4s and PTT-DCE-MRI was 10.4±2.0s (P=0.88). The correlations of PTT and nPTT by CEUS and DCE-MRI were strong; r=0.75 (P=0.0001) and r=0.76 (P=0.0001), respectively. Bland-Altman analysis revealed a bias of 0.1s for PTT. nPTT-CEUS correlated moderately with left ventricle volumes. The correlations for PTT-CEUS and nPTT-CEUS were moderate to strong with NT-proBNP; r=0.54 (P=0.022) and r=0.68 (P=0.002), respectively.

CONCLUSIONS: (n)PTT-CEUS showed strong agreement with that by DCE-MRI. Given the good correlation with NT-proBNP level, (n)PTT-CEUS may provide a novel, clinically feasible measure to quantify the severity of heart failure.

CLINICAL TRIAL REGISTRY: NCT01735838.

© 2016 The authors.

Keywords: B-type natriuretic peptide; cardiac magnetic resonance imaging; contrast echocardiography; heart failure; pulmonary transit time

References

  1. Congest Heart Fail. 2010 Jul;16 Suppl 1:S19-24 - PubMed
  2. J Vet Cardiol. 2013 Sep;15(3):181-7 - PubMed
  3. Eur Heart J. 2007 Jul;28(13):1592-7 - PubMed
  4. J Am Soc Echocardiogr. 1995 Sep-Oct;8(5 Pt 1):576-84 - PubMed
  5. J Clin Monit Comput. 2012 Oct;26(5):347-53 - PubMed
  6. Cardiovasc Ultrasound. 2009 Aug 20;7:39 - PubMed
  7. IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Sep;51(9):1137-47 - PubMed
  8. Acta Physiol Pharmacol Neerl. 1966;14(2):175-204 - PubMed
  9. Cardiovasc Ultrasound. 2013 Oct 17;11:36 - PubMed
  10. Lancet. 1986 Feb 8;1(8476):307-10 - PubMed
  11. J Am Coll Cardiol. 2004 Jul 7;44(1):1-9 - PubMed
  12. Radiology. 2003 Dec;229(3):743-8 - PubMed
  13. Cardiovasc Ultrasound. 2016 Jan 05;14 :1 - PubMed
  14. Circ Cardiovasc Imaging. 2011 Mar;4(2):130-8 - PubMed
  15. Br J Anaesth. 2015 Jul;115(1):53-60 - PubMed
  16. Cardiovasc Ultrasound. 2014 Oct 31;12 :44 - PubMed
  17. J Vet Intern Med. 2003 Nov-Dec;17 (6):824-9 - PubMed
  18. Pulm Circ. 2014 Mar;4(1):61-70 - PubMed
  19. Magn Reson Med. 2009 Feb;61(2):344-53 - PubMed
  20. J Vet Cardiol. 2015 Mar;17(1):25-33 - PubMed
  21. Echocardiography. 2015 Oct;32(10 ):1564-71 - PubMed
  22. J Am Coll Cardiol. 2004 Sep 1;44(5):1030-5 - PubMed
  23. Eur J Appl Physiol Occup Physiol. 1979 Feb 15;40(3):211-8 - PubMed
  24. J Am Coll Cardiol. 2002 Nov 6;40(9):1615-22 - PubMed
  25. Br Med J. 1965 Dec 18;2(5476):1466-9 - PubMed
  26. Pacing Clin Electrophysiol. 2013 Nov;36(11):1391-401 - PubMed

Publication Types