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Bukhryakov KV, Desyatkin VG, Rodionov VO. Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds. Chem Commun (Camb). 2016;52(48):7576-9doi: 10.1039/c6cc01984f.
Bukhryakov, K. V., Desyatkin, V. G., & Rodionov, V. O. (2016). Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds. Chemical communications (Cambridge, England), 52(48), 7576-9. https://doi.org/10.1039/c6cc01984f
Bukhryakov, Konstantin V, et al. "Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds." Chemical communications (Cambridge, England) vol. 52,48 (2016): 7576-9. doi: https://doi.org/10.1039/c6cc01984f
Bukhryakov KV, Desyatkin VG, Rodionov VO. Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds. Chem Commun (Camb). 2016 Jun 18;52(48):7576-9. doi: 10.1039/c6cc01984f. Epub 2016 May 24. PMID: 27216276.
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Chem Commun (Camb). 2016 Jun 18;52(48):7576-9. doi: 10.1039/c6cc01984f. Epub 2016 May 24.

Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds.

Chemical communications (Cambridge, England)

Konstantin V Bukhryakov, Victor G Desyatkin, Valentin O Rodionov

Affiliations

  1. KAUST Catalysis Center and Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia. [email protected].

PMID: 27216276 DOI: 10.1039/c6cc01984f

Abstract

A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed.

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