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Org Biomol Chem. 2016 Jun 15;14(24):5377-89. doi: 10.1039/c6ob00091f.

Trihaloethenes as versatile building blocks for organic synthesis.

Organic & biomolecular chemistry

Adriana S Grossmann, Thomas Magauer

Affiliations

  1. Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany. [email protected].

PMID: 27181133 DOI: 10.1039/c6ob00091f

Abstract

This review highlights the chemistry of trihaloethene building blocks with a special focus on commercially available 1,1,2-trichloroethene. The topics surveyed herein include the use of trihaloethenes as C2-building blocks for transition metal-catalyzed coupling reactions, addition, elimination and cycloaddition reactions as well as natural product syntheses.

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