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Dong J, Zink JI. Simultaneous spectroscopic measurements of the interior temperature and induced cargo release from pore-restricted mesoporous silica nanoparticles. Nanoscale. 2016;8(20):10558-63doi: 10.1039/c6nr00978f.
Dong, J., & Zink, J. I. (2016). Simultaneous spectroscopic measurements of the interior temperature and induced cargo release from pore-restricted mesoporous silica nanoparticles. Nanoscale, 8(20), 10558-63. https://doi.org/10.1039/c6nr00978f
Dong, Juyao, and Zink, Jeffrey I. "Simultaneous spectroscopic measurements of the interior temperature and induced cargo release from pore-restricted mesoporous silica nanoparticles." Nanoscale vol. 8,20 (2016): 10558-63. doi: https://doi.org/10.1039/c6nr00978f
Dong J, Zink JI. Simultaneous spectroscopic measurements of the interior temperature and induced cargo release from pore-restricted mesoporous silica nanoparticles. Nanoscale. 2016 May 19;8(20):10558-63. doi: 10.1039/c6nr00978f. PMID: 27150579.
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Nanoscale. 2016 May 19;8(20):10558-63. doi: 10.1039/c6nr00978f.

Simultaneous spectroscopic measurements of the interior temperature and induced cargo release from pore-restricted mesoporous silica nanoparticles.

Nanoscale

Juyao Dong, Jeffrey I Zink

Affiliations

  1. Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA. [email protected].

PMID: 27150579 DOI: 10.1039/c6nr00978f

Abstract

Temperature changes initiated within nano structures are being increasingly used to externally activate responsive delivery vehicles. Yet, the precise measurement of the nano environment temperature increase and its correlation with the induced macroscopic cargo release are difficult to achieve. In this study, we focus on a photothermally activated drug delivery system based on mesoporous silica nanoparticles, and use an optical nanothermometer - NaYF4:Yb(3+),Er(3+) crystals - for a ratiometric temperature measurement. Using fluorescent dyes as the payload molecule, both the nanoparticle interior temperature change and the macroscopic cargo release amount are monitored simultaneously by fluorescent spectroscopy. We found that the cargo release lags the temperature increase by about 5 min, revealing the threshold temperature that the particles have to reach before a substantial release could happen. Using this spectroscopic method, we are able to directly compare and correlate a nano environment event with its stimulated macroscopic results.

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Grant support