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Zhang JJ, Gao XF, Ge Z, et al. Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention. Patient Prefer Adherence. 2016;10:871-8doi: 10.2147/PPA.S104100.
Zhang, J. J., Gao, X. F., Ge, Z., Jiang, X. M., Xiao, P. X., Tian, N. L., Kan, J., Lee, C. H., & Chen, S. L. (2016). Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention. Patient preference and adherence, 10871-8. https://doi.org/10.2147/PPA.S104100
Zhang, Jun-Jie, et al. "Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention." Patient preference and adherence vol. 10 (2016): 871-8. doi: https://doi.org/10.2147/PPA.S104100
Zhang JJ, Gao XF, Ge Z, Jiang XM, Xiao PX, Tian NL, Kan J, Lee CH, Chen SL. Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention. Patient Prefer Adherence. 2016 May 20;10:871-8. doi: 10.2147/PPA.S104100. eCollection 2016. PMID: 27284240; PMCID: PMC4881919.
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Patient Prefer Adherence. 2016 May 20;10:871-8. doi: 10.2147/PPA.S104100. eCollection 2016.

Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention.

Patient preference and adherence

Jun-Jie Zhang, Xiao-Fei Gao, Zhen Ge, Xiao-Min Jiang, Ping-Xi Xiao, Nai-Liang Tian, Jing Kan, Chi-Hang Lee, Shao-Liang Chen

Affiliations

  1. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China; Department of Cardiology, Nanjing Heart Center, Nanjing, People's Republic of China.
  2. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
  3. Department of Cardiology, Nanjing Heart Center, Nanjing, People's Republic of China.
  4. Department of Cardiology, National University Heart Center, Singapore.

PMID: 27284240 PMCID: PMC4881919 DOI: 10.2147/PPA.S104100

Abstract

BACKGROUND: There is a paucity of evidence regarding the association between obstructive sleep apnea (OSA) and patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. We sought to investigate whether OSA affects the clinical outcomes of patients undergoing PCI.

PATIENTS AND METHODS: All enrolled individuals treated with PCI were evaluated for OSA by polysomnography. The primary end point was defined as major adverse cardiac events (MACEs) at 2 years, including cardiac death, myocardial infarction (MI), and/or target vessel revascularization.

RESULTS: A total of 340 consecutive patients undergoing PCI were assigned to the OSA (n=152, apnea-hypopnea index ≥15) and non-OSA (n=188, apnea-hypopnea index <15) groups. The incidence of OSA in patients with coronary artery disease undergoing PCI was 44.7%. Patients in the OSA group had more three-vessel disease (34.9%), increased number of total implanted stents (3.3±2.0), and longer total stent length (83.8±53.1 mm) when compared to the non-OSA group (23.4%, P=0.020; 2.8±1.9, P=0.007; 68.7±48.4, P=0.010). After a median follow-up of 2 years, the incidence of MACEs was significantly higher in patients with OSA (25.0% vs 16.0%, P=0.038), mainly driven by the increased periprocedural MI (19.2% vs 11.2%, P=0.038) in the OSA group. By Cox regression multivariable analysis, the independent predictor of MACEs was OSA (hazard ratio: 1.962, 95% confidence interval: 1.036-3.717, P=0.039).

CONCLUSION: There was a high prevalence of moderate-to-severe OSA in patients undergoing PCI, and OSA was associated with significantly increased MACE rate, mainly due to the increase in periprocedural MI rate.

Keywords: coronary artery disease; myocardial infarction; obstructive sleep apnea; percutaneous coronary intervention

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