Display options
Cite
Shiroma LS, Piazzetta MH, Duarte-Junior GF, et al. Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices. Sci Rep. 2016;6:26032doi: 10.1038/srep26032.
Shiroma, L. S., Piazzetta, M. H., Duarte-Junior, G. F., Coltro, W. K., Carrilho, E., Gobbi, A. L., & Lima, R. S. (2016). Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices. Scientific reports, 626032. https://doi.org/10.1038/srep26032
Shiroma, Letícia S, et al. "Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices." Scientific reports vol. 6 (2016): 26032. doi: https://doi.org/10.1038/srep26032
Shiroma LS, Piazzetta MH, Duarte-Junior GF, Coltro WK, Carrilho E, Gobbi AL, Lima RS. Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices. Sci Rep. 2016 May 16;6:26032. doi: 10.1038/srep26032. PMID: 27181918; PMCID: PMC4867595.
Copy Download .nbib Format: NLM
Share it on

Sci Rep. 2016 May 16;6:26032. doi: 10.1038/srep26032.

Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices.

Scientific reports

Letícia S Shiroma, Maria H O Piazzetta, Gerson F Duarte-Junior, Wendell K T Coltro, Emanuel Carrilho, Angelo L Gobbi, Renato S Lima

Affiliations

  1. Laboratório de Microfabricação, Laboratório Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo 13083-970, Brasil.
  2. Instituto de Química, Universidade Federal de Goiás, Goiânia, Goiás 74001-970, Brasil.
  3. Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo 13566-590, Brasil.

PMID: 27181918 PMCID: PMC4867595 DOI: 10.1038/srep26032

Abstract

This paper outlines a straightforward, fast, and low-cost method to fabricate polydimethylsiloxane (PDMS) chips. Termed sandwich bonding (SWB), this method requires only a laboratory oven. Initially, SWB relies on the reversible bonding of a coverslip over PDMS channels. The coverslip is smaller than the substrate, leaving a border around the substrate exposed. Subsequently, a liquid composed of PDMS monomers and a curing agent is poured onto the structure. Finally, the cover is cured. We focused on PDMS/glass chips because of their key advantages in microfluidics. Despite its simplicity, this method created high-performance microfluidic channels. Such structures featured self-regeneration after leakages and hybrid irreversible/reversible behavior. The reversible nature was achieved by removing the cover of PDMS with acetone. Thus, the PDMS substrate and glass coverslip could be detached for reuse. These abilities are essential in the stages of research and development. Additionally, SWB avoids the use of surface oxidation, half-cured PDMS as an adhesive, and surface chemical modification. As a consequence, SWB allows surface modifications before the bonding, a long time for alignment, the enclosure of sub-micron channels, and the prototyping of hybrid devices. Here, the technique was successfully applied to bond PDMS to Au and Al.

References

  1. Electrophoresis. 2004 Apr;25(7-8):1120-4 - PubMed
  2. Acc Chem Res. 2013 Nov 19;46(11):2396-406 - PubMed
  3. Small. 2013 Jan 14;9(1):9-21 - PubMed
  4. Lab Chip. 2015 Jul 7;15(13):2819-25 - PubMed
  5. Lab Chip. 2012 May 8;12(11):1963-6 - PubMed
  6. Lab Chip. 2012 May 8;12(11):1959-62 - PubMed
  7. Lab Chip. 2015 Oct 7;15(19):3856-61 - PubMed
  8. Lab Chip. 2006 Dec;6(12):1484-6 - PubMed
  9. Anal Chem. 1998 Dec 1;70(23):4974-84 - PubMed
  10. Anal Chem. 2003 Dec 1;75(23):6544-54 - PubMed
  11. Lab Chip. 2011 Dec 21;11(24):4148-51 - PubMed
  12. Lab Chip. 2009 Dec 21;9(24):3549-56 - PubMed
  13. Anal Chem. 2006 Nov 1;78(21):7446-52 - PubMed
  14. ACS Nano. 2012 May 22;6(5):4314-8 - PubMed
  15. Electrophoresis. 2000 Jan;21(1):27-40 - PubMed
  16. Electrophoresis. 2006 Jul;27(14):2917-23 - PubMed
  17. Anal Chem. 2006 Nov 1;78(21):7522-7 - PubMed
  18. Electrophoresis. 2007 Dec;28(24):4668-78 - PubMed
  19. Lab Chip. 2010 Mar 7;10(5):548-52 - PubMed
  20. Science. 2000 Apr 7;288(5463):113-6 - PubMed
  21. Langmuir. 2009 Apr 9;25(6):3861-6 - PubMed
  22. Anal Chem. 2005 Mar 1;77(5):1414-22 - PubMed
  23. Anal Chem. 2003 Sep 1;75(17):4572-7 - PubMed
  24. Lab Chip. 2012 Oct 21;12(20):4120-7 - PubMed
  25. Lab Chip. 2009 Oct 21;9(20):3016-9 - PubMed
  26. Sci Rep. 2015 Aug 21;5:13276 - PubMed
  27. Lab Chip. 2010 Feb 21;10(4):494-8 - PubMed
  28. Lab Chip. 2006 Dec;6(12):1548-9 - PubMed
  29. Lab Chip. 2008 Apr;8(4):516-8 - PubMed
  30. Langmuir. 2010 Jul 20;26(14):11609-14 - PubMed
  31. Lab Chip. 2013 Nov 21;13(22):4312-6 - PubMed
  32. Lab Chip. 2015 Jul 7;15(13):2749-53 - PubMed
  33. Analyst. 2010 Jan;135(1):96-103 - PubMed
  34. Chem Rev. 2013 Apr 10;113(4):2550-83 - PubMed
  35. Lab Chip. 2008 Aug;8(8):1379-85 - PubMed
  36. Conf Proc IEEE Eng Med Biol Soc. 2006;1:2486-9 - PubMed
  37. J Am Chem Soc. 2007 Jul 18;129(28):8825-35 - PubMed
  38. Lab Chip. 2007 Feb;7(2):199-206 - PubMed
  39. Electrophoresis. 2008 Dec;29(24):4928-37 - PubMed
  40. Lab Chip. 2011 Jan 21;11(2):348-53 - PubMed
  41. Chem Commun (Camb). 2013 Dec 18;49(97):11382-4 - PubMed
  42. Lab Chip. 2009 Feb 7;9(3):411-6 - PubMed
  43. Lab Chip. 2005 Dec;5(12):1393-8 - PubMed

Publication Types