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Zumárraga JP, Baptista AM, Rosa LP, et al. SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA. Acta Ortop Bras. 2016;24(3):142-6doi: 10.1590/1413-785220162403157033.
Zumárraga, J. P., Baptista, A. M., Rosa, L. P., Caiero, M. T., & Camargo, O. P. (2016). SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA. Acta ortopedica brasileira, 24(3), 142-6. https://doi.org/10.1590/1413-785220162403157033
Zumárraga, Juan Pablo, et al. "SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA." Acta ortopedica brasileira vol. 24,3 (2016): 142-6. doi: https://doi.org/10.1590/1413-785220162403157033
Zumárraga JP, Baptista AM, Rosa LP, Caiero MT, Camargo OP. SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA. Acta Ortop Bras. 2016 May-Jun;24(3):142-6. doi: 10.1590/1413-785220162403157033. PMID: 27217815; PMCID: PMC4863862.
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Acta Ortop Bras. 2016 May-Jun;24(3):142-6. doi: 10.1590/1413-785220162403157033.

SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA.

Acta ortopedica brasileira

Juan Pablo Zumárraga, André Mathias Baptista, Luis Pablo De La Rosa, Marcelo Tadeu Caiero, Olavo Pires De Camargo

Affiliations

  1. . Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto de Ortopedia e Traumatologia, São Paulo, SP, Brazil.

PMID: 27217815 PMCID: PMC4863862 DOI: 10.1590/1413-785220162403157033

Abstract

OBJECTIVE: To study the relationship between the pre and post chemotherapy (CT) serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) found in specimens after the pre surgical CT in patients with osteosarcoma.

METHODS: Series of cases with retrospective evaluation of patients diagnosed with osteosarcoma. Participants were divided into two groups according to serum values of both enzymes. The values of AP and LDH were obtained before and after preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens of each patient was also included.

RESULTS: One hundred and thirty seven medical records were included from 1990 to 2013. Both the AP as LDH decreased in the patients studied, being the higher in pre CT than post CT. The average LHD decrease was 795.12U/L and AP decrease was 437.40 U/L. The average TN was 34.10 %. There was no statistically significant correlation between the serums values and the percentage of tumoral necrosis.

CONCLUSION: The serum levels values of AP and LDH are not good predictors for the chemotherapy-induced necrosis in patients with osteosarcoma. Level of Evidence IV, Case Series.

Keywords: Alkaline phosphatase; Drug therapy; L-Lactate Dehydrogenase; Osteosarcoma; Prognosis.; Tumor necrosis factors

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