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Mokline A, Garsallah L, Rahmani I, et al. Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients. Ann Burns Fire Disasters. 2015;28(2):116-20
Mokline, A., Garsallah, L., Rahmani, I., Jerbi, K., Oueslati, H., Tlaili, S., Hammouda, R., Gasri, B., & Messadi, A. A. (2015). Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients. Annals of burns and fire disasters, 28(2), 116-20.
Mokline, A, et al. "Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients." Annals of burns and fire disasters vol. 28,2 (2015): 116-20.
Mokline A, Garsallah L, Rahmani I, Jerbi K, Oueslati H, Tlaili S, Hammouda R, Gasri B, Messadi AA. Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients. Ann Burns Fire Disasters. 2015 Jun 30;28(2):116-20. PMID: 27252609; PMCID: PMC4837487.
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Ann Burns Fire Disasters. 2015 Jun 30;28(2):116-20.

Procalcitonin: a diagnostic and prognostic biomarker of sepsis in burned patients.

Annals of burns and fire disasters

A Mokline, L Garsallah, I Rahmani, K Jerbi, H Oueslati, S Tlaili, R Hammouda, B Gasri, A A Messadi

Affiliations

  1. Burn Care Department, Burn and Trauma Center, Tunis, Tunisia.
  2. Laboratory of Clinical Biology, Burn and Trauma Center, Tunis, Tunisia.

PMID: 27252609 PMCID: PMC4837487

Abstract

The goal of this study was to analyse plasma procalcitonin (PCT) concentrations during infectious events of burns in ICU. We conducted a prospective, observational study in a 20-bed Burn Intensive Care Unit in Tunisia. A total of 121 patients admitted to the Burn ICU were included in our study. Serum PCT was measured over the entire course of stay in patients with predictive signs of sepsis according to the Americain Burn Association Criteria for the presence of infection. Patients were assigned to two groups depending on the clinical course and outcome: Group A = non septic patients; Group B = septic patients. A PCT cutoff value of 0,69 ng/ml for sepsis prediction was associated with the optimal combination of sensitivity (89%), specificity (85%), positive predictive value (82%) and negative predictive value (88%). Serum procalcitonin levels can be used as an early indicator of septic complication in patients with severe burn injuries as well as in monitoring the response to antimicrobial therapy.

Keywords: burns; procalcitonin (PCT); sepsis

References

  1. Burns. 2007 Nov;33(7):860-4 - PubMed
  2. Crit Care Med. 1991 Jul;19(7):973-6 - PubMed
  3. Burns. 2007 Mar;33(2):189-94 - PubMed
  4. Crit Care Med. 2003 Apr;31(4):1250-6 - PubMed
  5. Am J Respir Crit Care Med. 2001 Aug 1;164(3):396-402 - PubMed
  6. Shock. 2006 Jul;26(1):13-9 - PubMed
  7. J Burn Care Rehabil. 2004 Jan-Feb;25(1):76-80 - PubMed
  8. Burns. 1998 Dec;24(8):745-50 - PubMed
  9. J Trauma. 1981 Oct;21(10):862-9 - PubMed
  10. Burns. 2008 Sep;34(6):770-4 - PubMed
  11. Arch Surg. 2007 Jul;142(7):639-42 - PubMed
  12. Chest. 1992 Jun;101(6):1644-55 - PubMed
  13. N Engl J Med. 2001 Nov 8;345(19):1368-77 - PubMed
  14. J Burn Care Res. 2007 Nov-Dec;28(6):776-90 - PubMed
  15. Pathology. 2007 Aug;39(4):383-90 - PubMed
  16. Crit Care Med. 2003 Dec;31(12):2742-51 - PubMed
  17. Crit Care Med. 1999 Mar;27(3):498-504 - PubMed

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