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Kimura T, Kobayashi A, Tanaka N, et al. Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection. Hepatol Res. 2016;47(5):405-418doi: 10.1111/hepr.12762.
Kimura, T., Kobayashi, A., Tanaka, N., Sano, K., Komatsu, M., Fujimori, N., Yamazaki, T., Shibata, S., Ichikawa, Y., Joshita, S., Umemura, T., Matsumoto, A., Horiuchi, A., Mori, H., Wada, S., Kiyosawa, K., Miyagawa, S. I., & Tanaka, E. (2017). Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection. Hepatology research : the official journal of the Japan Society of Hepatology, 47(5), 405-418. https://doi.org/10.1111/hepr.12762
Kimura, Takefumi, et al. "Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection." Hepatology research : the official journal of the Japan Society of Hepatology vol. 47,5 (2017): 405-418. doi: https://doi.org/10.1111/hepr.12762
Kimura T, Kobayashi A, Tanaka N, Sano K, Komatsu M, Fujimori N, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Horiuchi A, Mori H, Wada S, Kiyosawa K, Miyagawa SI, Tanaka E. Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection. Hepatol Res. 2017 Apr;47(5):405-418. doi: 10.1111/hepr.12762. Epub 2016 Jul 24. PMID: 27288988.
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Hepatol Res. 2017 Apr;47(5):405-418. doi: 10.1111/hepr.12762. Epub 2016 Jul 24.

Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection.

Hepatology research : the official journal of the Japan Society of Hepatology

Takefumi Kimura, Akira Kobayashi, Naoki Tanaka, Kenji Sano, Michiharu Komatsu, Naoyuki Fujimori, Tomoo Yamazaki, Soichiro Shibata, Yuki Ichikawa, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Akira Horiuchi, Hiromitsu Mori, Shuichi Wada, Kendo Kiyosawa, Shin-Ichi Miyagawa, Eiji Tanaka

Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan.
  2. Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan.
  3. Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
  4. Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
  5. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
  6. Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.
  7. Department of Internal Medicine, Shironishi Hospital, Matsumoto, Japan.

PMID: 27288988 DOI: 10.1111/hepr.12762

Abstract

AIM: Past hepatitis B virus (HBV) infection is considered a risk factor for hepatocarcinogenesis, but the clinicopathological characteristics of non-B non-C hepatocellular carcinoma (NBNC-HCC) excluding past HBV infection have not been investigated. This study aimed to clarify the clinicopathological features of strictly defined NBNC-HCC.

METHODS: Among HCC patients who underwent surgical resection at our affiliated hospitals in Nagano prefecture, Japan, between 1996 and 2012, 77 were negative for serum anti-HBV core/surface antibodies in addition to HBV surface antigen and anti-hepatitis C virus antibody without signs of autoimmune liver disease, Wilson disease, or hemochromatosis. These patients were divided into the alcohol intake-positive group (ethanol intake >20 g/day, n = 31), non-alcoholic fatty liver group (steatosis >5% and ethanol intake <20 g/day, n = 30), and cryptogenic group (no ethanol intake or steatosis, n = 16). Preoperative clinical parameters, tumor and background liver pathology, and prognosis were analyzed.

RESULTS: Advanced fibrosis and steatosis were detected in 64% and 60% of all patients, respectively. Approximately 85% of the alcohol intake-positive patients had advanced fibrosis. Non-alcoholic fatty liver HCC subjects had the highest body mass index and prevalence of diabetes, but 30-40% had none to mild fibrosis. The cryptogenic group of HCC patients had the lowest incidence of accompanying hepatic inflammation/fibrosis but the largest tumor size. Recurrence/survival rates were comparable among the groups.

CONCLUSIONS: Liver fibrosis and steatosis are risk factors of HCC regardless of past HBV infection and ethanol consumption. The present results also indicate the possibility of hepatocarcinogenesis independent of hepatic steatosis, inflammation and fibrosis, ethanol intake, and past HBV infection.

© 2016 The Japan Society of Hepatology.

Keywords: diabetes; liver fibrosis; non-B non-B hepatocellular carcinoma; normal liver; obesity; past HBV infection

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