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Bihar E, Deng Y, Miyake T, et al. A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor. Sci Rep. 2016;6:27582doi: 10.1038/srep27582.
Bihar, E., Deng, Y., Miyake, T., Saadaoui, M., Malliaras, G. G., & Rolandi, M. (2016). A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor. Scientific reports, 627582. https://doi.org/10.1038/srep27582
Bihar, Eloїse, et al. "A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor." Scientific reports vol. 6 (2016): 27582. doi: https://doi.org/10.1038/srep27582
Bihar E, Deng Y, Miyake T, Saadaoui M, Malliaras GG, Rolandi M. A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor. Sci Rep. 2016 Jun 13;6:27582. doi: 10.1038/srep27582. PMID: 27291059; PMCID: PMC4904368.
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Sci Rep. 2016 Jun 13;6:27582. doi: 10.1038/srep27582.

A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor.

Scientific reports

Eloїse Bihar, Yingxin Deng, Takeo Miyake, Mohamed Saadaoui, George G Malliaras, Marco Rolandi

Affiliations

  1. Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541 Gardanne, France.
  2. Microvitae Technologies, Hôtel Technologique, Europarc Sainte Victoire, Route de Valbrillant, Meyreuil, 13590, France.
  3. Department of Flexible Electronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541 Gardanne, France.
  4. Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
  5. Department of Electrical Engineering, University of California, Santa Cruz, CA, 95064, USA.

PMID: 27291059 PMCID: PMC4904368 DOI: 10.1038/srep27582

Abstract

UNLABELLED: Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor. The OECT is made with the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (

PEDOT: PSS), and is printed on paper. ADH and its cofactor nicotinamide adenine dinucleotide (NAD(+)) are immobilized onto the OECT with an electrolyte gel. When the OECT-breathalyzer is exposed to ethanol vapor, the enzymatic reaction of ADH and ethanol transforms NAD(+) into NADH, which causes a decrease in the OECT source drain current. In this fashion, the OECT-breathalyzer easily detects ethanol in the breath equivalent to BAC from 0.01% to 0.2%. The use of a printed OECT may contribute to the development of breathalyzers that are disposable, ecofriendly, and integrated with wearable devices for real-time BAC monitoring.

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