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El-Sadek AE, Behery EG, Azab AA, et al. Arginine dimethylation products in pediatric patients with chronic kidney disease. Ann Med Surg (Lond). 2016;9:22-7doi: 10.1016/j.amsu.2016.05.017.
El-Sadek, A. E., Behery, E. G., Azab, A. A., Kamal, N. M., Salama, M. A., Abdulghany, W. E., & Abdallah, E. A. (2016). Arginine dimethylation products in pediatric patients with chronic kidney disease. Annals of medicine and surgery (2012), 922-7. https://doi.org/10.1016/j.amsu.2016.05.017
El-Sadek, Akram E, et al. "Arginine dimethylation products in pediatric patients with chronic kidney disease." Annals of medicine and surgery (2012) vol. 9 (2016): 22-7. doi: https://doi.org/10.1016/j.amsu.2016.05.017
El-Sadek AE, Behery EG, Azab AA, Kamal NM, Salama MA, Abdulghany WE, Abdallah EA. Arginine dimethylation products in pediatric patients with chronic kidney disease. Ann Med Surg (Lond). 2016 Jun 02;9:22-7. doi: 10.1016/j.amsu.2016.05.017. eCollection 2016 Aug. PMID: 27358729; PMCID: PMC4915955.
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Ann Med Surg (Lond). 2016 Jun 02;9:22-7. doi: 10.1016/j.amsu.2016.05.017. eCollection 2016 Aug.

Arginine dimethylation products in pediatric patients with chronic kidney disease.

Annals of medicine and surgery (2012)

Akram E El-Sadek, Eman G Behery, Ahmed A Azab, Naglaa M Kamal, Mostafa A Salama, Waleed E Abdulghany, Enas A A Abdallah

Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Benha University, Egypt.
  2. Department of Clinical Pathology, Faculty of Medicine, Benha University, Egypt.
  3. Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

PMID: 27358729 PMCID: PMC4915955 DOI: 10.1016/j.amsu.2016.05.017

Abstract

BACKGROUND: arginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function.

PATIENTS AND METHODS: 132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels.

RESULTS: In comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: < 0.000; = 0.054; <0.000, respectively). Calculated Arg/ADMA and Arg/SDMA ratios were significantly higher in patients compared to controls (p values: 0.001, and <0.000, respectively). However ADMA/SDMA ratio was significantly lower in patients compared to controls (p = 0.001. Serum Arg levels showed positive significant correlation, while serum ADMA and SDMA levels showed negative significant correlation with eGFR. Moreover, Arg/ADMA ratio showed negative significant correlation, while ADMA/SDMA ratio showed positive significant correlation with eGFR of patients. Regression analysis defined high serum SDMA level as persistently significant predictor for low eGFR.

CONCLUSION: Disturbed serum levels of arginine and its dimethyl derivatives may underlie development and/or progression of CKD. Elevated serum SDMA level is strongly correlated with impaired kidney functions and could be considered as a predictor for kidney functions deterioration and CKD progression.

Keywords: Chronic kidney disease; Kidney functions; Serum arginine; Serum dimethyl arginine derivatives

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