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Wan TW, Tomita Y, Saita N, et al. Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly. New Microbes New Infect. 2016;13:17-21doi: 10.1016/j.nmni.2016.05.011.
Wan, T. W., Tomita, Y., Saita, N., Konno, K., Iwao, Y., Hung, W. C., Teng, L. J., & Yamamoto, T. (2016). Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly. New microbes and new infections, 1317-21. https://doi.org/10.1016/j.nmni.2016.05.011
Wan, T-W, et al. "Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly." New microbes and new infections vol. 13 (2016): 17-21. doi: https://doi.org/10.1016/j.nmni.2016.05.011
Wan TW, Tomita Y, Saita N, Konno K, Iwao Y, Hung WC, Teng LJ, Yamamoto T. Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly. New Microbes New Infect. 2016 May 26;13:17-21. doi: 10.1016/j.nmni.2016.05.011. eCollection 2016 Sep. PMID: 27358743; PMCID: PMC4917487.
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New Microbes New Infect. 2016 May 26;13:17-21. doi: 10.1016/j.nmni.2016.05.011. eCollection 2016 Sep.

Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly.

New microbes and new infections

T-W Wan, Y Tomita, N Saita, K Konno, Y Iwao, W-C Hung, L-J Teng, T Yamamoto

Affiliations

  1. Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Centre, Niigata, Japan; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
  2. Developmental Therapeutics Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  3. Konno Hospital, Fukuoka, Japan.
  4. Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Centre, Niigata, Japan.
  5. Department of Microbiology and Immunology, Kaohsiung Medical University, Kaohsiung, Taiwan.
  6. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.

PMID: 27358743 PMCID: PMC4917487 DOI: 10.1016/j.nmni.2016.05.011

Abstract

The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an emerging type, originated in ST121/agr4 S. aureus, with diversities of Panton-Valentine leucocidin (PVL)(-)/spat5110/SCCmecV(+) versus PVL(+)/spat159((etc.))/SCCmec (-), but with common virulence potentials of strong adhesin and cytolytic activities. Resistance to erythromycin/clindamycin (inducible-type) and gentamicin was detected. Pneumonia improved with the administration of levofloxacin, but with the subsequent development of fatal aspiration pneumonia. Hence, characteristic CA-MRSA with strong adhesin and cytolytic activities triggered influenza-related sequential complications.

Keywords: Community-associated methicillin-resistant Staphylococcus aureus; ST121/agr4 lineage; elderly community-acquired pneumonia; fatal aspiration pneumonia; influenza

References

  1. J Med Microbiol. 2015 Dec;64(12):1462-73 - PubMed
  2. Curr Opin Immunol. 2014 Aug;29:105-11 - PubMed
  3. Emerg Infect Dis. 2006 Jun;12(6):894-9 - PubMed
  4. Antimicrob Agents Chemother. 2009 Dec;53(12):4961-7 - PubMed
  5. PLoS One. 2009 Aug 13;4(8):e6630 - PubMed
  6. J Infect Dis. 2008 Jan 15;197(2):195-204 - PubMed
  7. Science. 2010 Jan 22;327(5964):469-74 - PubMed
  8. Infect Immun. 2015 Oct;83(10):3764-70 - PubMed
  9. JAMA. 2007 Oct 17;298(15):1763-71 - PubMed
  10. Arch Gerontol Geriatr. 2016 Jul-Aug;65:116-21 - PubMed
  11. Trends Microbiol. 2008 Aug;16(8):361-9 - PubMed
  12. Br J Radiol. 2012 Jun;85(1014):e168-75 - PubMed
  13. J Microbiol Immunol Infect. 2015 Oct;48(5):565-73 - PubMed
  14. Lancet. 2010 May 1;375(9725):1557-68 - PubMed
  15. Emerg Infect Dis. 2008 Aug;14(8):1312-4 - PubMed
  16. FEMS Immunol Med Microbiol. 2012 Jun;65(1):5-22 - PubMed
  17. N Engl J Med. 2015 Jul 30;373(5):415-27 - PubMed
  18. J Infect Dis. 2010 May 15;201(10):1589-97 - PubMed
  19. Clin Microbiol Rev. 2010 Jul;23(3):616-87 - PubMed
  20. Nat Med. 2007 Dec;13(12):1510-4 - PubMed
  21. Int J Pediatr. 2011;2011:143872 - PubMed
  22. J Infect Dis. 2004 Oct 15;190(8):1506-15 - PubMed
  23. Biomed Res. 2012 Apr;33(2):97-109 - PubMed
  24. PLoS One. 2010 Jan 14;5(1):e8705 - PubMed
  25. J Med Microbiol. 2009 Jan;58(Pt 1):13-25 - PubMed
  26. PLoS One. 2015 Jun 05;10(6):e0128017 - PubMed

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