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Chou IC, Lai HC, Tsai FJ, et al. Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO4 treatment in a 12-year-old girl. Epilepsy Behav Case Rep. 2016;6:6-9doi: 10.1016/j.ebcr.2016.05.002.
Chou, I. C., Lai, H. C., Tsai, F. J., Chang, Y. T., Lin, S. S., Hong, S. Y., & Lee, I. C. (2016). Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO4 treatment in a 12-year-old girl. Epilepsy & behavior case reports, 66-9. https://doi.org/10.1016/j.ebcr.2016.05.002
Chou, I-Ching, et al. "Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO4 treatment in a 12-year-old girl." Epilepsy & behavior case reports vol. 6 (2016): 6-9. doi: https://doi.org/10.1016/j.ebcr.2016.05.002
Chou IC, Lai HC, Tsai FJ, Chang YT, Lin SS, Hong SY, Lee IC. Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO4 treatment in a 12-year-old girl. Epilepsy Behav Case Rep. 2016 Jun 02;6:6-9. doi: 10.1016/j.ebcr.2016.05.002. eCollection 2016. PMID: 27358770; PMCID: PMC4917485.
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Epilepsy Behav Case Rep. 2016 Jun 02;6:6-9. doi: 10.1016/j.ebcr.2016.05.002. eCollection 2016.

Marked improvement in febrile infection-related epilepsy syndrome after lidocaine plus MgSO4 treatment in a 12-year-old girl.

Epilepsy & behavior case reports

I-Ching Chou, Huan-Cheng Lai, Fuu-Jen Tsai, Yu-Tzu Chang, Sheng-Shing Lin, Syuan-Yu Hong, Inn-Chi Lee

Affiliations

  1. Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
  2. Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan.
  3. Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan; Department of Medical Research, China Medical University and Hospital, Taichung, Taiwan.
  4. Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

PMID: 27358770 PMCID: PMC4917485 DOI: 10.1016/j.ebcr.2016.05.002

Abstract

PURPOSE: This report sheds light on a successful treatment in febrile infection-related epilepsy syndrome (FIRES) with the combined use of lidocaine and MgSO4.

METHODS: We report a 12-year-old previously healthy girl who experienced an upper respiratory infection with fever and headache for 2 days, then suddenly went into a coma followed by repetitive status epilepticus. All tests for CNS infection, metabolic and toxic diseases, and autoimmune encephalitis were negative. Hence, the diagnosis of FIRES was made. During 5 weeks of hospital treatment, various antiepileptic drugs were administered at different times without success. To achieve seizure control, we then attempted the use of lidocaine first, then followed by MgSO4.

RESULTS: The SE was successfully controlled when lidocaine plus MgSO4 was introduced. At follow-up, almost no neurological sequelae remained.

CONCLUSION: This is the first report describing the combined use of lidocaine and MgSO4 with successful treatment outcomes. This experience has indicated that even FIRES can be controlled if treated promptly with certain agents. However, more studies are needed to explore the mechanisms and effects of lidocaine and MgSO4 in FIRES.

Keywords: FIRES; Febrile infection-related epilepsy syndrome; Lidocaine; MgSO4; Status epilepticus

References

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