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Tian T, Wang M, Ma D. TNF-α, a good or bad factor in hematological diseases?. Stem Cell Investig. 2014;1:12doi: 10.3978/j.issn.2306-9759.2014.04.02.
Tian, T., Wang, M., & Ma, D. (2014). TNF-α, a good or bad factor in hematological diseases?. Stem cell investigation, 112. https://doi.org/10.3978/j.issn.2306-9759.2014.04.02
Tian, Tian, et al. "TNF-α, a good or bad factor in hematological diseases?." Stem cell investigation vol. 1 (2014): 12. doi: https://doi.org/10.3978/j.issn.2306-9759.2014.04.02
Tian T, Wang M, Ma D. TNF-α, a good or bad factor in hematological diseases?. Stem Cell Investig. 2014 Jun 01;1:12. doi: 10.3978/j.issn.2306-9759.2014.04.02. eCollection 2014. PMID: 27358858; PMCID: PMC4923506.
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Stem Cell Investig. 2014 Jun 01;1:12. doi: 10.3978/j.issn.2306-9759.2014.04.02. eCollection 2014.

TNF-α, a good or bad factor in hematological diseases?.

Stem cell investigation

Tian Tian, Min Wang, Daoxin Ma

Affiliations

  1. Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.

PMID: 27358858 PMCID: PMC4923506 DOI: 10.3978/j.issn.2306-9759.2014.04.02

Abstract

Tumor necrosis factor-alpha (TNF-α) is a highly pleiotropic cytokine involved in a spectrum of physiological processes that control inflammation, anti-tumor responses and homeostasis through two receptors, TNF-R1 and TNF-R2. In general, TNF-R1 mediates cytotoxicity, resistance to infection and stimulation of NF-κB. By contrast, TNF-R2 has been implicated in proliferation of T-cell line, thymocytes and human mononuclear cells. Hematological malignancies are the types of cancer that affect normal hematopoiesis, have a speedy development, high lethal rate and until now still have no effective treatment. Several studies have shown that inflammatory cytokines play an important role in the onset and progress of these diseases. In this review, we summarize the recent studies and evaluate the positive or negative role of TNF-α in some hematological malignancies or diseases with a malignant tendency.

Keywords: Tumor necrosis factor-alpha (TNF-α); hematological diseases

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