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Jaitly V, Wang W, Hu S. Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia. Stem Cell Investig. 2015;2:13doi: 10.3978/j.issn.2306-9759.2015.06.01.
Jaitly, V., Wang, W., & Hu, S. (2015). Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia. Stem cell investigation, 213. https://doi.org/10.3978/j.issn.2306-9759.2015.06.01
Jaitly, Vanya, et al. "Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia." Stem cell investigation vol. 2 (2015): 13. doi: https://doi.org/10.3978/j.issn.2306-9759.2015.06.01
Jaitly V, Wang W, Hu S. Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia. Stem Cell Investig. 2015 Jul 01;2:13. doi: 10.3978/j.issn.2306-9759.2015.06.01. eCollection 2015. PMID: 27358881; PMCID: PMC4923655.
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Stem Cell Investig. 2015 Jul 01;2:13. doi: 10.3978/j.issn.2306-9759.2015.06.01. eCollection 2015.

Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia.

Stem cell investigation

Vanya Jaitly, Wei Wang, Shimin Hu

Affiliations

  1. Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

PMID: 27358881 PMCID: PMC4923655 DOI: 10.3978/j.issn.2306-9759.2015.06.01

Abstract

Although defined by the presence of t(9;22), chronic myelogenous leukemia (CML) can have other concurrent additional cytogenetic changes, especially during disease progression. Additional chromosomal changes (ACAs) in CML often occur in Philadelphia chromosome (Ph)-positive cells and are associated with disease acceleration and treatment resistance. Occasionally chromosomal changes occur in Ph-negative cells and this phenomenon is often transient and does not correlate with disease progression. Very rarely myelodysplastic syndrome or acute leukemia can develop in Ph-negative cells. In this study, we report an unusual case of acute myeloid leukemia (AML) with 11q23/MLL translocation emerging from Ph-negative cells in a patient with CML.

Keywords: 11q23; MLL; Philadelphia chromosome (Ph)-negative AML; chronic myelogenous leukemia (CML)

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