Display options
Cite
Iwase T, Takao S, Akaike M, et al. Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy. Heart Asia. 2010;2(1):52-5doi: 10.1136/ha.2010.002006.
Iwase, T., Takao, S., Akaike, M., Adachi, K., Sumitomo-Ueda, Y., Yagi, S., Niki, T., Kusunose, K., Tomita, N., Hirata, Y., Yamaguchi, K., Koshiba, K., Taketani, Y., Yamada, H., Soeki, T., Wakatsuki, T., Aihara, K., Harada, M., Nishitani, H., & Sata, M. (2010). Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy. Heart Asia, 2(1), 52-5. https://doi.org/10.1136/ha.2010.002006
Iwase, Takashi, et al. "Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy." Heart Asia vol. 2,1 (2010): 52-5. doi: https://doi.org/10.1136/ha.2010.002006
Iwase T, Takao S, Akaike M, Adachi K, Sumitomo-Ueda Y, Yagi S, Niki T, Kusunose K, Tomita N, Hirata Y, Yamaguchi K, Koshiba K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Aihara K, Harada M, Nishitani H, Sata M. Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy. Heart Asia. 2010 Jul 29;2(1):52-5. doi: 10.1136/ha.2010.002006. eCollection 2010. PMID: 27325943; PMCID: PMC4898527.
Copy Download .nbib Format: NLM
Share it on

Heart Asia. 2010 Jul 29;2(1):52-5. doi: 10.1136/ha.2010.002006. eCollection 2010.

Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.

Heart Asia

Takashi Iwase, Shoichiro Takao, Masashi Akaike, Katsuhito Adachi, Yuka Sumitomo-Ueda, Shusuke Yagi, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Yoichiro Hirata, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-Ichi Aihara, Masafumi Harada, Hiromu Nishitani, Masataka Sata

Affiliations

  1. Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
  2. Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
  3. Department of Internal Medicine and Neurology, Tokushima National Hospital, Tokushima, Japan.
  4. Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
  5. Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

PMID: 27325943 PMCID: PMC4898527 DOI: 10.1136/ha.2010.002006

Abstract

BACKGROUND: Cardiac involvement is a recognised complication in female carriers of Duchenne muscular dystrophy (DMD). Since segmental or global left ventricle (LV) wall motion abnormalities in DMD carriers can arise even without apparent muscle weakness, it is difficult to differentiate cardiac involvement of a DMD carrier from other heart diseases in a non-invasive manner. Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) enables assessment of regional wall motion abnormality and myocardial damage with high spatial resolution.

OBJECTIVE: To assess the utility of CMR for detection of myocardial damage in female carriers of DMD.

METHODS AND RESULTS: Gadolinium-enhanced CMR was performed in seven female DMD carriers. Physical examination, electrocardiography, chest radiograph, measurements of total creatinine kinase and brain natriuretic peptide levels, and two-dimensional echocardiography were also performed. Four (57%) of the seven carriers had LGE, and LGE was frequently observed at the subepicardial layer in the inferolateral segment. Two carriers had a focal LGE at the LV inferolateral wall without LV dilation or wall motion abnormalities.

CONCLUSION: CMR findings of DMD carriers were characterised by subepicardial LGE, which was localised at inferolateral segments. CMR may be a useful modality for detecting cardiac involvement in DMD carriers.

Keywords: MRI; cardiomyopathies; gadolinium; muscular dystrophies

References

  1. Intern Med. 1997 Jul;36(7):497-500 - PubMed
  2. Circulation. 2002 Aug 27;106(9):1083-9 - PubMed
  3. Circulation. 1999 Nov 9;100(19):1992-2002 - PubMed
  4. Lancet. 2002 Feb 23;359(9307):687-95 - PubMed
  5. Neuromuscul Disord. 2003 Feb;13(2):166-72 - PubMed
  6. Pediatrics. 2005 Dec;116(6):1569-73 - PubMed
  7. Neuromuscul Disord. 2001 Mar;11(2):186-91 - PubMed
  8. Circulation. 2002 Jan 29;105(4):539-42 - PubMed
  9. Neuromuscul Disord. 1999 Jul;9(5):347-51 - PubMed
  10. Circulation. 2003 Jul 8;108(1):54-9 - PubMed
  11. AJR Am J Roentgenol. 2005 May;184(5):1420-6 - PubMed
  12. J Am Soc Echocardiogr. 2005 Dec;18(12 ):1440-63 - PubMed
  13. Heart. 2009 Oct;95(20):1688-93 - PubMed
  14. Lancet. 1999 Jun 19;353(9170):2116-9 - PubMed
  15. Neuromuscul Disord. 2003 Feb;13(2):129-32 - PubMed
  16. Cardiology. 2003;99(1):1-19 - PubMed
  17. Heart. 2008 May;94(5):633-6 - PubMed
  18. Int J Cardiol. 2010 Feb 4;138(3):302-5 - PubMed
  19. Neuromuscul Disord. 1998 Dec;8(8):585-90 - PubMed
  20. JAMA. 1996 May 1;275(17):1335-8 - PubMed
  21. J Am Coll Cardiol. 2006 Nov 21;48(10):1977-85 - PubMed

Publication Types