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Panahi Y, Pishgoo B, Sahebkar A. Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial. Heart Views. 2015;16(3):85-7doi: 10.4103/1995-705X.164462.
Panahi, Y., Pishgoo, B., & Sahebkar, A. (2015). Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial. Heart views : the official journal of the Gulf Heart Association, 16(3), 85-7. https://doi.org/10.4103/1995-705X.164462
Panahi, Yunes, et al. "Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial." Heart views : the official journal of the Gulf Heart Association vol. 16,3 (2015): 85-7. doi: https://doi.org/10.4103/1995-705X.164462
Panahi Y, Pishgoo B, Sahebkar A. Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial. Heart Views. 2015 Jul-Sep;16(3):85-7. doi: 10.4103/1995-705X.164462. PMID: 27326348; PMCID: PMC4590189.
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Heart Views. 2015 Jul-Sep;16(3):85-7. doi: 10.4103/1995-705X.164462.

Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial.

Heart views : the official journal of the Gulf Heart Association

Yunes Panahi, Bahram Pishgoo, Amirhossein Sahebkar

Affiliations

  1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  2. Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  3. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.

PMID: 27326348 PMCID: PMC4590189 DOI: 10.4103/1995-705X.164462

Abstract

BACKGROUND: Heracleum persicum is a common dietary spice with several traditional medicinal properties important for cardiovascular health including antioxidant, hypolipidemic, and anti-inflammatory effects. This study explored the effects of supplementation with H. persicum fruit on the angiographic findings of patients with minimal coronary artery disease (CAD).

METHODS: Subjects who were diagnosed with <50% stenosis in any of their coronary arteries by angiography were selected for this trial and randomly assigned to H. persicum hydroalcoholic fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. At the end of the trial, participants underwent a second coronary angiography in order to evaluate the progression of their disease.

RESULTS: Posttrial angiography did not reveal any improvement in the number of stenosed vessels after consumption of H. persicum extract versus placebo (P > 0.05). Similarly, there was no significant difference between the study groups in terms of disease progression and chest pain score (P > 0.05).

CONCLUSIONS: The present results do not support any clinically significant benefit of supplementation with H. persicum extract on the angiographic findings of in patients with minimal CAD.

Keywords: Angiography; Heracleum persicum; herbal pharmacotherapy; ischaemic heart disease; randomized controlled trial

References

  1. Prog Lipid Res. 2014 Oct;56:47-66 - PubMed
  2. Curr Med Chem. 2013;20(21):2641-60 - PubMed
  3. J Ethnopharmacol. 2009 Jul 30;124(3):475-80 - PubMed
  4. Drug Discov Today. 2015 Sep;20(9):1074-86 - PubMed
  5. Circulation. 2014 Jan 21;129(3):e28-e292 - PubMed
  6. ScientificWorldJournal. 2011 Mar 07;11:592-601 - PubMed
  7. Eur Heart J. 2006 Feb;27(3):296-301 - PubMed
  8. Am J Epidemiol. 2004 Dec 15;160(12):1223-33 - PubMed
  9. Am J Clin Nutr. 2003 Sep;78(3 Suppl):517S-520S - PubMed

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