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Suzuki S, Nishimura N, Jinta T, et al. Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report. Multidiscip Respir Med. 2016;11:25doi: 10.1186/s40248-016-0060-5.
Suzuki, S., Nishimura, N., Jinta, T., Yamano, Y., Ishikawa, G., Tomishima, Y., Uchiyama, N., & Chohnabayashi, N. (2016). Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report. Multidisciplinary respiratory medicine, 1125. https://doi.org/10.1186/s40248-016-0060-5
Suzuki, Shoji, et al. "Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report." Multidisciplinary respiratory medicine vol. 11 (2016): 25. doi: https://doi.org/10.1186/s40248-016-0060-5
Suzuki S, Nishimura N, Jinta T, Yamano Y, Ishikawa G, Tomishima Y, Uchiyama N, Chohnabayashi N. Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report. Multidiscip Respir Med. 2016 Jun 20;11:25. doi: 10.1186/s40248-016-0060-5. eCollection 2016. PMID: 27326370; PMCID: PMC4913422.
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Multidiscip Respir Med. 2016 Jun 20;11:25. doi: 10.1186/s40248-016-0060-5. eCollection 2016.

Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report.

Multidisciplinary respiratory medicine

Shoji Suzuki, Naoki Nishimura, Torahiko Jinta, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Noboru Uchiyama, Naohiko Chohnabayashi

Affiliations

  1. Division of Pulmonary Medicine, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo City, Tokyo 104-8560 Japan.

PMID: 27326370 PMCID: PMC4913422 DOI: 10.1186/s40248-016-0060-5

Abstract

BACKGROUND: Early identification and control of pathogenic bacteria are important in the treatment of pneumonia. Currently, two rapid antigen detection kits for pneumococcal pneumonia are available: one uses urine samples and the other, named RAPIRUN® S. pneumoniae, uses sputum samples. RAPIRUN® has shown high sensitivity with nasopharyngeal swab samples from pediatric patients. In this study, we investigated the performance of RAPIRUN® with nasopharyngeal swabs from adult patients.

METHODS: All adult patients diagnosed with pneumonia from November 2011 to April 2012 in St. Luke's International hospital were included in this cross-sectional study. Single sputum, nasopharyngeal swab, and urine samples obtained from patients were investigated using a rapid antigen detection kit. Sputum and blood cultures were also evaluated. We compared the characteristics of pneumococcal pneumonia patients diagnosed using RAPIRUN with a nasopharyngeal swab to those patients diagnosed using other methods. Sensitivity and specificity were also calculated.

RESULTS: Seventeen out of 60 patients with pneumonia were diagnosed with pneumococcal pneumonia. In 4 out  of the 17 cases, a positive test result was obtained using RAPIRUN with a nasopharyngeal swab. The sensitivity and specificity were 23.5 and 100 %, respectively.

CONCLUSION: RAPIRUN performed with nasopharyngeal swabs from adult patients exhibited lower sensitivity for the diagnosis of pneumococcal pneumonia than the other compared methods. The causative pathogen of pneumonia should be identified using not only sputum cultures or rapid antigen detection kits but also clinical features or gram staining of sputum.

Keywords: Immunochromatographic assay; Nasopharyngeal swab; Pneumonia; RAPIRUN® S. pneumoniae

References

  1. Trans R Soc Trop Med Hyg. 2014 Jun;108(6):326-37 - PubMed
  2. Respirology. 2013 Nov;18(8):1177-83 - PubMed
  3. Chest. 2001 Jan;119(1):243-9 - PubMed
  4. Clin Vaccine Immunol. 2009 May;16(5):672-8 - PubMed
  5. Am Rev Respir Dis. 1971 Jun;103(6):845-8 - PubMed
  6. J Infect Chemother. 2015 Mar;21(3):176-81 - PubMed
  7. Clin Infect Dis. 2003 Feb 1;36(3):286-92 - PubMed
  8. Lancet. 2005 Mar 26-Apr 1;365(9465):1139-46 - PubMed
  9. J Clin Microbiol. 1987 May;25(5):758-62 - PubMed
  10. Eur J Clin Microbiol Infect Dis. 2013 Mar;32(3):305-16 - PubMed
  11. J Med Microbiol. 2008 Jul;57(Pt 7):820-6 - PubMed
  12. Thorax. 2012 Jan;67(1):71-9 - PubMed

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