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Shido K, Fujimura T, Kakizaki A, et al. Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor. Case Rep Dermatol. 2016;8(1):26-30doi: 10.1159/000444045.
Shido, K., Fujimura, T., Kakizaki, A., Furudate, S., Asano, M., & Aiba, S. (2016). Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor. Case reports in dermatology, 8(1), 26-30. https://doi.org/10.1159/000444045
Shido, Kosuke, et al. "Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor." Case reports in dermatology vol. 8,1 (2016): 26-30. doi: https://doi.org/10.1159/000444045
Shido K, Fujimura T, Kakizaki A, Furudate S, Asano M, Aiba S. Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor. Case Rep Dermatol. 2016 Feb 05;8(1):26-30. doi: 10.1159/000444045. eCollection 2016. PMID: 27293390; PMCID: PMC4899637.
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Case Rep Dermatol. 2016 Feb 05;8(1):26-30. doi: 10.1159/000444045. eCollection 2016.

Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor.

Case reports in dermatology

Kosuke Shido, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masayuki Asano, Setsuya Aiba

Affiliations

  1. Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

PMID: 27293390 PMCID: PMC4899637 DOI: 10.1159/000444045

Abstract

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.

Keywords: Immunomodulation; Periostin; Plexiform fibrohistiocytic tumor; Tumor-associated macrophages

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