Conserv Physiol. 2014 Dec 03;2(1):cou058. doi: 10.1093/conphys/cou058. eCollection 2014.
Chronic exposure to a low dose of ingested petroleum disrupts corticosterone receptor signalling in a tissue-specific manner in the house sparrow (Passer domesticus).
Conservation physiology
Christine R Lattin, L Michael Romero
Affiliations
Affiliations
- Department of Biology, Tufts University, Medford, MA 02155, USA.
PMID: 27293679
PMCID: PMC4732471 DOI: 10.1093/conphys/cou058
Abstract
Stress-induced concentrations of glucocorticoid hormones (including corticosterone, CORT) can be suppressed by chronic exposure to a low dose of ingested petroleum. However, endocrine-disrupting chemicals could interfere with CORT signalling beyond the disruption of hormone titres, including effects on receptors in different target tissues. In this study, we examined the effects of 6 weeks of exposure to a petroleum-laced diet (1% oil weight:food weight) on tissue mass and intracellular CORT receptors in liver, fat, muscle and kidney (metabolic tissues), spleen (an immune tissue) and testes (a reproductive tissue). In the laboratory, male house sparrows were fed either a 1% weathered crude oil (n = 12) or a control diet (n = 12); glucocorticoid receptors and mineralocorticoid receptors were quantified using radioligand binding assays. In oil-exposed birds, glucocorticoid receptors were lower in one metabolic tissue (liver), higher in another metabolic tissue (fat) and unchanged in four other tissues (kidney, muscle, spleen and testes) compared with control birds. We saw no differences in mineralocorticoid receptors between groups. We also saw a trend towards reduced mass of the testes in oil-exposed birds compared with controls, but no differences in fat, kidney, liver, muscle or spleen mass between the two groups. This is the first study to examine the effects of petroleum on CORT receptor density in more than one or two target tissues. Given that a chronic low dose of ingested petroleum can affect stress-induced CORT titres as well as receptor density, this demonstrates that oil can act at multiple levels to disrupt an animal's response to environmental stressors. This also highlights the potential usefulness of the stress response as a bioindicator of chronic crude oil exposure.
Keywords: bird; endocrine disruption; glucocorticoid receptor; hypothalamic–pituitary–adrenal axis; mineralocorticoid receptor; toxicology
References
- Biochem Pharmacol. 2009 Feb 15;77(4):474-84 - PubMed
- Ecotoxicology. 2009 Jul;18(5):514-21 - PubMed
- Gen Comp Endocrinol. 2008 Jul;157(3):266-74 - PubMed
- Gen Comp Endocrinol. 2000 Oct;120(1):27-34 - PubMed
- Neuroendocrinology. 1987 May;45(5):407-12 - PubMed
- Endocr Rev. 1998 Jun;19(3):269-301 - PubMed
- Endocr Rev. 1996 Dec;17(6):587-609 - PubMed
- PLoS One. 2014 Jul 16;9(7):e102106 - PubMed
- Brain Res. 1991 May 24;549(2):236-46 - PubMed
- J Neuroendocrinol. 2001 May;13(5):412-20 - PubMed
- Aquat Toxicol. 2004 Apr 28;67(3):273-85 - PubMed
- Environ Sci Technol. 2004 Jan 1;38(1):19-25 - PubMed
- Brain Behav Immun. 2010 Aug;24(6):908-18 - PubMed
- J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):387-94 - PubMed
- Aquat Toxicol. 2000 Nov;51(1):45-54 - PubMed
- Physiol Res. 2008;57(3):427-35 - PubMed
- Endocrinology. 2002 Nov;143(11):4184-95 - PubMed
- Endocrinology. 1990 Aug;127(2):759-65 - PubMed
- Environ Toxicol Chem. 2008 Nov;27(11):2326-31 - PubMed
- Physiol Rev. 2013 Jul;93(3):1139-206 - PubMed
- J Exp Zool. 1992 Dec 15;264(4):419-28 - PubMed
- J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):222-31 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R787-93 - PubMed
- Vet Clin Pathol. 2002;31(3):140-51 - PubMed
- Endocrinology. 1984 Jan;114(1):287-92 - PubMed
- Environ Health Perspect. 1998 Dec;106(12):769-72 - PubMed
- Comp Biochem Physiol C. 1981;68C(2):103-7 - PubMed
- Environ Sci Technol. 2002 Nov 15;36(22):4754-60 - PubMed
- Endocr Rev. 2000 Feb;21(1):55-89 - PubMed
- Trends Ecol Evol. 2004 May;19(5):249-55 - PubMed
- Avian Dis. 2012 Dec;56(4):704-10 - PubMed
- Chem Res Toxicol. 2004 Aug;17(8):1064-76 - PubMed
- Gen Comp Endocrinol. 2006 Sep 1;148(2):132-49 - PubMed
- Environ Sci Technol. 2009 Aug 1;43(15):6031-8 - PubMed
- J Wildl Dis. 1982 Apr;18(2):235-41 - PubMed
- J Steroid Biochem. 1989 Jan;32(1A):99-104 - PubMed
- Physiol Biochem Zool. 1999 Mar-Apr;72(2):250-3 - PubMed
- Environ Res. 1982 Feb;27(1):206-15 - PubMed
- Toxicol Sci. 2006 Nov;94(1):3-21 - PubMed
- Arch Environ Contam Toxicol. 1982;11(4):497-502 - PubMed
- Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):111-20 - PubMed
- Annu Rev Pharmacol Toxicol. 2003;43:309-34 - PubMed
- Toxicol Sci. 2006 Sep;93(1):41-9 - PubMed
- Gen Comp Endocrinol. 2009 Sep 1;163(1-2):214-24 - PubMed
- Ecotoxicology. 2003 Feb-Aug;12(1-4):199-208 - PubMed
- Mol Endocrinol. 1987 Jan;1(1):68-74 - PubMed
- J Exp Biol. 2014 Jul 15;217(Pt 14):2601-8 - PubMed
- Gen Comp Endocrinol. 2012 Nov 1;179(2):214-20 - PubMed
- Environ Res. 1984 Apr;33(2):343-52 - PubMed
- Environ Res. 1979 Dec;20(2):425-44 - PubMed
- Br Med J. 1963 Oct 12;2(5362):887-91 - PubMed
- Placenta. 1984 Mar-Apr;5(2):105-16 - PubMed
- Aquat Toxicol. 2009 Jun 4;93(1):70-82 - PubMed
- Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):309-15 - PubMed
Publication Types