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Jin GY, Lv CZ, Tang D, et al. Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. Asian Pac J Trop Med. 2016;9(7):702-6doi: 10.1016/j.apjtm.2016.05.005.
Jin, G. Y., Lv, C. Z., Tang, D., Cheng, S. W., & Li, C. Q. (2016). Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. Asian Pacific journal of tropical medicine, 9(7), 702-6. https://doi.org/10.1016/j.apjtm.2016.05.005
Jin, Gui-Yun, et al. "Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism." Asian Pacific journal of tropical medicine vol. 9,7 (2016): 702-6. doi: https://doi.org/10.1016/j.apjtm.2016.05.005
Jin GY, Lv CZ, Tang D, Cheng SW, Li CQ. Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism. Asian Pac J Trop Med. 2016 Jul;9(7):702-6. doi: 10.1016/j.apjtm.2016.05.005. Epub 2016 May 29. PMID: 27393102.
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Asian Pac J Trop Med. 2016 Jul;9(7):702-6. doi: 10.1016/j.apjtm.2016.05.005. Epub 2016 May 29.

Effect of partial splenic embolization on the immune function of cirrhosis patients with hypersplenism.

Asian Pacific journal of tropical medicine

Gui-Yun Jin, Chuan-Zhu Lv, Deng Tang, Shao-Wen Cheng, Chao-Qian Li

Affiliations

  1. Guangxi Medical University, China.
  2. Hainan Medical University, China.
  3. The Affiliate Hospital of Hainan Medical College, China.
  4. Guangxi Medical University, China. Electronic address: [email protected].

PMID: 27393102 DOI: 10.1016/j.apjtm.2016.05.005

Abstract

OBJECTIVE: To discover the effect of partial splenic embolization on the immune function of cirrhotic patients with hypersplenism.

METHODS: Patients involved in the study were enrolled and divided into three groups, including control group, experimental group, and complication group. Numbers of CD3(+), CD4(+) and CD8(+) T cells and CD4(+)CD25(+)CDl27(low/-) Treg cells in the peripheral blood of patients before surgery, 1 month, 6 months, 1 year, and 2 years after surgery were analyzed by fluorescence active cell sorting (FACS). Contents of immunoglobulins (IgA, IgG and IgM) were analyzed by auto immunoassay analyzer.

RESULTS: In the peripheral blood of patients from experimental group, numbers of CD3(+), CD4(+) and CD8(+) T cells initially declined, but afterwards increased to normal level; in the peripheral blood of patients from complication group, CD3(+) and CD8(+) T cells showed the same trend, but the number of CD4(+) T cells was below normal level at all detection times. Furthermore, CD3(+), CD4(+) and CD8(+) T cells in the peripheral blood of patients from complication group were initially less than those in experimental group, and afterwards were comparable between two groups. In patients from both experimental group and complication group, the number of CD4(+) CD25(+) CDl27(low/-)Treg cells increased 1 month and 6 months after surgery, and gradually restored to normal level. CD4(+)CD25(+)CDl27(low/-) Treg cell counts in patients from complication group were initially more than those in patients from experimental group 1 month and 6 months after surgery, but then they were comparable. Furthermore, contents of immunoglobulins (IgA, IgG and IgM) were comparable in three groups at all detection times.

CONCLUSION: Partial splenic embolization influenced the immune function of cirrhotic patients with hypersplenism in the short term but the immune function could afterwards gradually restore to normal. Our results implicated that measures that prevent infection and improve immune function were necessary in early stage after undergoing PSE in order to reduce complications.

Copyright © 2016 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

Keywords: Cirrhosis; Hypersplenism; Immune function; Partial splenic embolization; Viral hepatitis type B

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