Display options
Cite
Chebane L, Tavassoli N, Bagheri H, et al. Hyperglycémies d'origine médicamenteuse : étude dans la Base Nationale Française de PharmacoVigilance (BNPV). [Not Available]. Therapie. 2010;65(5):447-58doi: 10.2515/therapie/2010051.
Chebane, L., Tavassoli, N., Bagheri, H., Jean-LouisMontastruc. (2010). Hyperglycémies d'origine médicamenteuse : étude dans la Base Nationale Française de PharmacoVigilance (BNPV). [Not Available]. Therapie, 65(5), 447-58. https://doi.org/10.2515/therapie/2010051
Chebane, Leila, et al. "Hyperglycémies d'origine médicamenteuse : étude dans la Base Nationale Française de PharmacoVigilance (BNPV)." [Not Available]. Therapie vol. 65,5 (2010): 447-58. doi: https://doi.org/10.2515/therapie/2010051
Chebane L, Tavassoli N, Bagheri H, Jean-LouisMontastruc. Hyperglycémies d'origine médicamenteuse : étude dans la Base Nationale Française de PharmacoVigilance (BNPV). [Not Available]. Therapie. 2010 Sep-Oct;65(5):447-58. doi: 10.2515/therapie/2010051. French. PMID: 27393246.
Copy Download .nbib Format: NLM
Share it on

Therapie. 2010 Sep-Oct;65(5):447-58. doi: 10.2515/therapie/2010051.

[Not Available].

Therapie

[Article in French]
Leila Chebane, Neda Tavassoli, Haleh Bagheri, Jean-LouisMontastruc,

Affiliations

  1. Laboratoire de Pharmacologie Médicale et Clinique, Unité de Pharmacoépidémiologie EA 3696, Université de Toulouse, Faculté de Médecine, Toulouse, France.
  2. Laboratoire de Pharmacologie Médicale et Clinique, Unité de Pharmacoépidémiologie EA 3696, Université de Toulouse, Faculté de Médecine, Toulouse, France; Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Centre Hospitalier Universitaire de Toulouse, France.
  3. Laboratoire de Pharmacologie Médicale et Clinique, Unité de Pharmacoépidémiologie EA 3696, Université de Toulouse, Faculté de Médecine, Toulouse, France; Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Centre Hospitalier Universitaire de Toulouse, France. Electronic address: [email protected].

PMID: 27393246 DOI: 10.2515/therapie/2010051

Abstract

OBJECTIVE: To analyse drugs inducing hyperglycemia by using data reported to the French spontaneous reporting system and recorded in the French PharmacoVigilance Database (FPVD).

METHODS: All cases with a report of hyperglycemia and/or diabetes in the French database between 1985 and 2008 were included in the study. We estimated the risk of hyperglycemia linked to drugs by the case/non-case method. Cases were reports including hyperglycemia and non cases all other reports. This risk was estimated through calculation of reporting odds ratios (ROR).

RESULTS: During this period, 1219 reports including the words "hyperglycemia and/or diabetes" were registered (0.34% of the database). This adverse drug reaction occurred 1 fold over 4 in diabetics or as a part of HIV infection. Effect was "serious" in approximatively 50% of cases.We found an increase of risk during exposition with methylprednisolone [ROR=43.5; 95% CI (37.3-50.8)], tacrolimus [ROR=25; 95% CI (17.9-34.8)], olanzapine [ROR=19.9; 95% CI (14.9-26.5)], prednisone [ROR=18.9; 95% CI (15.7-22.8)] or pentamidine [ROR=15.4; 95% CI (8.2-28.3)].

CONCLUSION: Drug classes most frequently found in FPVD linked to hyperglycemia are antiretroviral, steroidal anti-inflammatory, second generation neuroleptic, immunosuppressive and diuretic drugs.

Copyright © 2010 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.

Keywords: Pharmacovigilance; adverse drug reactions; diabetes; diabète; drugs; effets indésirables; hyperglycemia; hyperglycémie; médicaments

Publication Types