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Ma QL, Guo YQ, Shi B, et al. For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?. J Thorac Dis. 2016;8(6):1227-33doi: 10.21037/jtd.2016.04.60.
Ma, Q. L., Guo, Y. Q., Shi, B., Tian, Y. C., Song, Z. Y., & Liu, D. R. (2016). For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?. Journal of thoracic disease, 8(6), 1227-33. https://doi.org/10.21037/jtd.2016.04.60
Ma, Qian-Li, et al. "For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?." Journal of thoracic disease vol. 8,6 (2016): 1227-33. doi: https://doi.org/10.21037/jtd.2016.04.60
Ma QL, Guo YQ, Shi B, Tian YC, Song ZY, Liu DR. For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?. J Thorac Dis. 2016 Jun;8(6):1227-33. doi: 10.21037/jtd.2016.04.60. PMID: 27293841; PMCID: PMC4886029.
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J Thorac Dis. 2016 Jun;8(6):1227-33. doi: 10.21037/jtd.2016.04.60.

For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?.

Journal of thoracic disease

Qian-Li Ma, Yong-Qing Guo, Bin Shi, Yan-Chu Tian, Zhi-Yi Song, De-Ruo Liu

Affiliations

  1. Department of Thoracic Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.

PMID: 27293841 PMCID: PMC4886029 DOI: 10.21037/jtd.2016.04.60

Abstract

BACKGROUND: Pneumonectomy (PN) has traditionally been the treatment of choice for central lung tumors for which the alternative is sleeve lobectomy (SL). The aim of this study was to compare early and long-term results after SL and PN in focusing on T3 central non-small cell lung cancer (NSCLC).

METHODS: Patients who underwent SL (n=58) or PN (n=42) were retrospectively analyzed. For bias reduction, these 100 patients had been selected according to the following criteria: (I) tumor located in the main bronchus less than 2 cm distal to the carina; (II) there were no N2 disease; (III) no induction therapy was applied; (IV) complete resection (R0) was achieved.

RESULTS: SL and PN patients had comparable mean ages, gender distribution, mean forced expiratory volume in 1 second (FEV1), stage and tumor grade. Postoperative mortality (3.4% vs. 4.8%, P=1.0) and morbidity (41% vs. 38%, P=0.74) were similar between the two groups. Recurrences occurred in 48% of patients after SL and in 31% of those after PN (P=0.08). The 5-year survival after SL (64.8%) and PN (61.4%) was not significantly different (P=0.20). Multivariable survival analysis showed that there were no independent prognostic factors.

CONCLUSIONS: SL does not compromise survival for NSCLC with T3 central disease compared with PN. It is an adequate oncologic resection and should be treated as the first line intervention whenever complete resection can be achieved.

Keywords: Sleeve lobectomy (SL); lung neoplasm; pneumonectomy (PN)

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