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Chaabane A, Aouam K, Fredj NB, et al. DRESS syndrome : étude de 11 cas et revue de la littérature. [Not Available]. Therapie. 2010;65(6):543-50doi: 10.2515/therapie/2010072.
Chaabane, A., Aouam, K., Fredj, N. B., & Boughattas, N. A. (2010). DRESS syndrome : étude de 11 cas et revue de la littérature. [Not Available]. Therapie, 65(6), 543-50. https://doi.org/10.2515/therapie/2010072
Chaabane, Amel, et al. "DRESS syndrome : étude de 11 cas et revue de la littérature." [Not Available]. Therapie vol. 65,6 (2010): 543-50. doi: https://doi.org/10.2515/therapie/2010072
Chaabane A, Aouam K, Fredj NB, Boughattas NA. DRESS syndrome : étude de 11 cas et revue de la littérature. [Not Available]. Therapie. 2010 Nov-Dec;65(6):543-50. doi: 10.2515/therapie/2010072. French. PMID: 27393273.
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Therapie. 2010 Nov-Dec;65(6):543-50. doi: 10.2515/therapie/2010072.

[Not Available].

Therapie

[Article in French]
Amel Chaabane, Karim Aouam, Nadia Ben Fredj, Naceur A Boughattas

Affiliations

  1. Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie. Electronic address: [email protected].
  2. Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.

PMID: 27393273 DOI: 10.2515/therapie/2010072

Abstract

AIM: Study the epidemiological, clinical, biological and chronological drug rash with eosinophilia and systemic symptoms (DRESS) characteristic and indicate the implicated drugs.

METHODS: We carried a retrospective study including all DRESS cases notified to the Pharmacovigilance Unit of Monastir.

RESULTS: Our cohort of eleven patients had a median age of 40 years. Clinical examination revealed skin eruption and fever among all patients. Laboratory findings showed marked eosinophilia among all patients, hepatic cytolysis among eight patients and creatinin serum level increase among four patients. An interstitial pulmonary syndrome was noted among two patients. After culprit-drug withdrawal, outcomes were favorable for all patients. Skin tests were positive with carbamazepin and cefotaxim and negative with sulfasalazine, allopurinol and terbinafine.

CONCLUSION: Throughout this paper, we point out the contribution of skin tests to identify implicated drug in inducing DRESS and to testify cross reactivity and we point out the possibility of neosensitisation to a non related chemical drug after DRESS syndrome.

Copyright © 2010 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.

Keywords: DRESS; HHV6; drugs; médicaments; pharmacovigilance; skin tests; tests cutanés

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