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Bahari Javan N, Rezaie Shirmard L, Jafary Omid N, et al. Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide. J Microencapsul. 2016;33(5):460-474doi: 10.1080/02652048.2016.1208296.
Bahari Javan, N., Rezaie Shirmard, L., Jafary Omid, N., Akbari Javar, H., Rafiee Tehrani, M., & Abedin Dorkoosh, F. (2016). Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide. Journal of microencapsulation, 33(5), 460-474. https://doi.org/10.1080/02652048.2016.1208296
Bahari Javan, Nika, et al. "Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide." Journal of microencapsulation vol. 33,5 (2016): 460-474. doi: https://doi.org/10.1080/02652048.2016.1208296
Bahari Javan N, Rezaie Shirmard L, Jafary Omid N, Akbari Javar H, Rafiee Tehrani M, Abedin Dorkoosh F. Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide. J Microencapsul. 2016 Aug;33(5):460-474. doi: 10.1080/02652048.2016.1208296. Epub 2016 Jul 17. PMID: 27424890.
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J Microencapsul. 2016 Aug;33(5):460-474. doi: 10.1080/02652048.2016.1208296. Epub 2016 Jul 17.

Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide.

Journal of microencapsulation

Nika Bahari Javan, Leila Rezaie Shirmard, Nersi Jafary Omid, Hamid Akbari Javar, Morteza Rafiee Tehrani, Farid Abedin Dorkoosh

Affiliations

  1. a Faculty of Pharmacy, Department of Pharmaceutics , Tehran University of Medical Sciences , Tehran , Iran (the Islamic Republic of).

PMID: 27424890 DOI: 10.1080/02652048.2016.1208296

Abstract

The purpose of this study was the preparation, optimisation and in vitro characterisation of PHBV and PLGA blend nanoparticles (NPs) for prolonged delivery of Teriparatide. Double emulsion solvent evaporation technique was employed for the fabrication of NPs. The nanoformulation was optimised using the Box-Behnken methodology. The morphological properties of NPs were assessed by both SEM and transmission electron microscopy (TEM). Encapsulation of Teriparatide within the NPs and lacking of chemical bonds between drug and copolymers were proved by XRPD, FTIR and DSC. The structural stability of Teriparatide after processing was confirmed by fluorescence spectrometry. The average size of optimised NPs was 250.0 nm with entrapment efficiency (EE) of 89.5% and drug loading (DL) of 5.0%. Teriparatide release from optimised NPs led to 64.4% release over 30 days and it showed a diffusion-based mechanism. Based on the favourable results, PHBV/PLGA blend NPs could be a promising candidate for designing a controlled release formulation of Teriparatide.

Keywords: Box–Behnken’s design; Poly (3-hydroxybutyrate-co-3-hydroxyvalerate); Teriparatide; blend nanoparticles; poly (lactic-co-glycolic acid); prolonged delivery

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