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Case Rep Oncol Med. 2016;2016:7149821. doi: 10.1155/2016/7149821. Epub 2016 May 18.

Neuroendocrine Cancer of Rectum Metastasizing to Ovary.

Case reports in oncological medicine

Sapna Vinit Amin, Aswathy Kumaran, Sunanda Bharatnur, Akhila Vasudeva, Kartik Udupa, Dinesh Bangalore Venkateshiah, Shaila T Bhat

Affiliations

  1. Department of OBG, Kasturba Medical College, Manipal University, Manipal 576104, India.
  2. IVF and Reproductive Biology Centre, Maulana Azad Medical College, New Delhi 110002, India.
  3. Department of Medical Oncology, Kasturba Medical College, Manipal University, Manipal 576104, India.
  4. Department of Surgery, Kasturba Medical College, Manipal University, Manipal 576104, India.
  5. Department of Pathology, Melaka Manipal Medical College, Manipal University, Manipal 576104, India.

PMID: 27293931 PMCID: PMC4887623 DOI: 10.1155/2016/7149821

Abstract

Neuroendocrine carcinomas (NECs) are rare malignancies that originate from the hormone-producing cells of the body's neuroendocrine system. Rectal high grade NEC (HG-NEC) constituting less than 1% of colorectal cancers can cause large ovarian metastasis that may be the initial presenting complaint. Ovarian Krukenberg tumor from a primary rectal HG-NEC is a very unusual and exceedingly uncommon differential diagnosis for secondary ovarian malignancy. This case report describes one such extremely rare case of a woman who had presented to the gynecology department with features suggestive of ovarian malignancy and was ultimately diagnosed to have Krukenberg tumor originating from neuroendocrine cancer of rectum. We felt this is a good opportunity to spread more light on neuroendocrine neoplasms that are very rare in gynecological practice.

References

  1. Virchows Arch. 2006 Oct;449(4):395-401 - PubMed
  2. Hum Pathol. 2009 Sep;40(9):1262-8 - PubMed
  3. J Clin Oncol. 2008 Jun 20;26(18):3063-72 - PubMed
  4. Cancer Metastasis Rev. 2011 Mar;30 Suppl 1:3-7 - PubMed
  5. Ann Surg Oncol. 2014 Sep;21(9):2956-62 - PubMed
  6. Am J Surg Pathol. 2008 May;32(5):719-31 - PubMed
  7. Br J Cancer. 2004 May 4;90(9):1720-6 - PubMed
  8. Endokrynol Pol. 2013;64(1):60-72 - PubMed
  9. Pancreas. 2010 Aug;39(6):799-800 - PubMed
  10. Cancer. 1991 Jul 15;68(2):227-32 - PubMed
  11. Neuroendocrinology. 2009;89(3):296-301 - PubMed
  12. Br J Cancer. 1999 Dec;81(8):1351-5 - PubMed
  13. Indian J Surg Oncol. 2016 Mar;7(1):73-8 - PubMed
  14. Pancreas. 2010 Aug;39(6):735-52 - PubMed
  15. Semin Oncol. 2013 Feb;40(1):100-8 - PubMed
  16. J Endocrinol Invest. 2008 Mar;31(3):277-86 - PubMed

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