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Boada-Sucre AA, Rossi Spadafora MS, Tavares-Marques LM, et al. Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep. Patholog Res Int. 2016;2016:4503214doi: 10.1155/2016/4503214.
Boada-Sucre, A. A., Rossi Spadafora, M. S., Tavares-Marques, L. M., Finol, H. J., & Reyna-Bello, A. (2016). Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep. Pathology research international, 20164503214. https://doi.org/10.1155/2016/4503214
Boada-Sucre, Alpidio A, et al. "Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep." Pathology research international vol. 2016 (2016): 4503214. doi: https://doi.org/10.1155/2016/4503214
Boada-Sucre AA, Rossi Spadafora MS, Tavares-Marques LM, Finol HJ, Reyna-Bello A. Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep. Patholog Res Int. 2016;2016:4503214. doi: 10.1155/2016/4503214. Epub 2016 May 16. PMID: 27293960; PMCID: PMC4884851.
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Patholog Res Int. 2016;2016:4503214. doi: 10.1155/2016/4503214. Epub 2016 May 16.

Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep.

Pathology research international

Alpidio A Boada-Sucre, Marcello Salvatore Rossi Spadafora, Lucinda M Tavares-Marques, Héctor J Finol, Armando Reyna-Bello

Affiliations

  1. Laboratorio de Microscopía Electrónica, Centro de Estudios Biomédicos y Veterinarios, Instituto de Estudios Científicos y Tecnológicos, Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela.
  2. Unidad de Toxoplasmosis y Protozoosis, Departamento de Parasitología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Calle Alejandro Casona 7, Piso 6D, 28035 Madrid, Spain; Sección de Inmunohistoquímica y Microscopía Electrónica, Instituto Anatomopatológico "José A. O'Daly", Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
  3. Grupo de Inmunobiología, Centro de Estudios Biomédicos y Veterinarios, Instituto de Estudios Científicos y Tecnológicos, Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela.
  4. Centro de Microscopía Electrónica "Mitsuo Ogura", Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela.
  5. Grupo de Inmunobiología, Centro de Estudios Biomédicos y Veterinarios, Instituto de Estudios Científicos y Tecnológicos, Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela; Investigador Prometeo, Universidad de Las Fuerzas Armadas ESPE, Departamento de Ciencias de la Vida, Grupo de Investigación de Sanidad Animal y Humana (GISAH), Sangolquí, Ecuador.

PMID: 27293960 PMCID: PMC4884851 DOI: 10.1155/2016/4503214

Abstract

Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by Trypanosoma vivax. Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with T. vivax. Ovine infection resulted in changes of RBC shape as well as the formation of surface holes or vesicles. A frequent observation was the adhesion to the ovine RBC by the trypanosome's free flagellum, cell body, or attached flagellum in a process mediated by the filopodia emission from the trypanosome surface. The observed RBC alterations are caused by mechanical and biochemical damage from host-parasite interactions occurring in the bloodstream. The altered erythrocytes are prone to mononuclear phagocytic removal contributing to the hematocrit decrease during infection.

References

  1. Vet Res. 2011 May 11;42:63 - PubMed
  2. J Protozool. 1973 Aug;20(3):394-404 - PubMed
  3. Trans R Soc Trop Med Hyg. 1980;74(2):268-70 - PubMed
  4. Parasitol Today. 1993 Jun;9(6):222-5 - PubMed
  5. BMC Genomics. 2013 Mar 05;14:149 - PubMed
  6. Exp Parasitol. 2005 Oct;111(2):126-9 - PubMed
  7. Rev Inst Med Trop Sao Paulo. 1962 Nov-Dec;4:389-96 - PubMed
  8. Vet Res. 2009 Nov-Dec;40(6):52 - PubMed
  9. Cell Microbiol. 2013 Aug;15(8):1285-303 - PubMed
  10. Vet Res. 2013 Jan 04;44:1 - PubMed
  11. Biochimie. 1998 Feb;80(2):173-95 - PubMed
  12. Nature. 1960 Dec 17;188:1011-2 - PubMed
  13. Parasitology. 2008 Sep;135(11):1303-15 - PubMed
  14. Exp Parasitol. 1970 Feb;27(1):1-8 - PubMed
  15. J Comp Pathol. 1983 Apr;93(2):165-9 - PubMed
  16. Mol Biochem Parasitol. 1988 Jun;29(2-3):159-69 - PubMed
  17. Vet Parasitol. 2011 Dec 15;182(2-4):359-63 - PubMed
  18. Lab Invest. 1982 Nov;47(5):412-26 - PubMed
  19. Parasitol Res. 1999 May;85(5):424-8 - PubMed
  20. Vet Parasitol. 2007 Jan 31;143(2):174-81 - PubMed
  21. Rev Elev Med Vet Pays Trop. 1988;41(1):65-78 - PubMed
  22. Vet Parasitol. 2009 Jun 10;162(3-4):192-9 - PubMed
  23. Vet Pathol. 1992 Jan;29(1):33-45 - PubMed
  24. Clin Exp Immunol. 2005 Mar;139(3):405-10 - PubMed
  25. J Submicrosc Cytol Pathol. 2001 Jan-Apr;33(1-2):65-71 - PubMed
  26. Vet Parasitol. 1990 Jan;34(4):295-301 - PubMed
  27. Scand J Immunol Suppl. 1992;11:34-6 - PubMed
  28. Trop Anim Health Prod. 1994 Nov;26(4):213-8 - PubMed
  29. J Comp Pathol. 1994 Jan;110(1):79-89 - PubMed
  30. J Submicrosc Cytol Pathol. 1999 Oct;31(4):509-13 - PubMed
  31. Am J Vet Res. 1983 Apr;44(4):639-44 - PubMed
  32. Exp Parasitol. 2010 Mar;124(3):301-5 - PubMed
  33. Trans R Soc Trop Med Hyg. 1970;64(6):797-817 - PubMed
  34. Parasitology. 1987 Oct;95 ( Pt 2):291-300 - PubMed
  35. Parasitol Res. 1995;81(5):412-20 - PubMed

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