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Kali A, Bhuvaneshwar D, Charles PM, et al. Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates. J Basic Clin Pharm. 2016;7(3):93-6doi: 10.4103/0976-0105.183265.
Kali, A., Bhuvaneshwar, D., Charles, P. M., & Seetha, K. S. (2016). Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates. Journal of basic and clinical pharmacy, 7(3), 93-6. https://doi.org/10.4103/0976-0105.183265
Kali, Arunava, et al. "Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates." Journal of basic and clinical pharmacy vol. 7,3 (2016): 93-6. doi: https://doi.org/10.4103/0976-0105.183265
Kali A, Bhuvaneshwar D, Charles PM, Seetha KS. Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates. J Basic Clin Pharm. 2016 Jun;7(3):93-6. doi: 10.4103/0976-0105.183265. PMID: 27330262; PMCID: PMC4910474.
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J Basic Clin Pharm. 2016 Jun;7(3):93-6. doi: 10.4103/0976-0105.183265.

Antibacterial synergy of curcumin with antibiotics against biofilm producing clinical bacterial isolates.

Journal of basic and clinical pharmacy

Arunava Kali, Devaraj Bhuvaneshwar, Pravin M V Charles, Kunigal Srinivasaiah Seetha

Affiliations

  1. Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

PMID: 27330262 PMCID: PMC4910474 DOI: 10.4103/0976-0105.183265

Abstract

INTRODUCTION: The role of natural bioactive substances in treating infections has been rediscovered as bacterial resistance become common to most of the antibiotics. Curcumin is a bioactive substance from turmeric. Owing to antimicrobial properties, its prospect as an antibacterial agent is currently under focus.

MATERIALS AND METHODS: We have evaluated the in vitro synergy of curcumin with antibiotics against sixty biofilm producing bacterial isolates. Congo red agar method was used to identify the biofilm producing isolates. Curcumin minimum inhibitory concentration (MIC) was determined by agar dilution method. Its antibiotic synergy was identified by the increase in disc diffusion zone size on Mueller-Hinton agar with 32 mg/L curcumin.

RESULTS: The mean MICs of curcumin against Gram-positive and Gram-negative isolates were 126.9 mg/L and 117.4 mg/L, respectively. Maximum synergy was observed with ciprofloxacin among Gram-positive and amikacin, gentamicin, and cefepime among Gram-negative isolates.

CONCLUSIONS: Curcumin per se as well as in combination with other antibiotics has a demonstrable antibacterial action against biofilm producing bacterial isolates. It may have a beneficial role in supplementing antibiotic therapy.

Keywords: Antibacterial synergy; Curcuma longa; antibiotic; curcumin

References

  1. Pak J Pharm Sci. 2015 Nov;28(6):2109-14 - PubMed
  2. Clin Microbiol Rev. 2012 Jan;25(1):193-213 - PubMed
  3. Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):389-397 - PubMed
  4. Pathog Dis. 2014 Apr;70(3):212-8 - PubMed
  5. Phytomedicine. 2013 Jun 15;20(8-9):714-8 - PubMed
  6. Toxicol Ind Health. 2016 Feb;32(2):246-50 - PubMed
  7. Front Microbiol. 2015 Apr 10;6:290 - PubMed
  8. Food Chem. 2014 Apr 1;148:453-60 - PubMed
  9. Mikrobiyol Bul. 2013 Jan;47(1):192-4 - PubMed
  10. Appl Microbiol Biotechnol. 2013 Dec;97(23):10177-87 - PubMed
  11. PLoS One. 2015 Mar 26;10(3):e0121313 - PubMed
  12. J Asian Nat Prod Res. 2014;16(5):535-41 - PubMed
  13. Biomed Res Int. 2014;2014:561456 - PubMed
  14. J Surg Res. 2011 Oct;170(2):302-8 - PubMed

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