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Ünal DY, Baran İ, Mutlu M, et al. Comparison of Sugammadex versus Neostigmine Costs and Respiratory Complications in Patients with Obstructive Sleep Apnoea. Turk J Anaesthesiol Reanim. 2015;43(6):387-95doi: 10.5152/TJAR.2015.35682.
Ünal, D. Y., Baran, �. �., Mutlu, M., Ural, G., Akkaya, T., & Özlü, O. (2015). Comparison of Sugammadex versus Neostigmine Costs and Respiratory Complications in Patients with Obstructive Sleep Apnoea. Turkish journal of anaesthesiology and reanimation, 43(6), 387-95. https://doi.org/10.5152/TJAR.2015.35682
Ünal, Dilek Yazıcıoğlu, et al. "Comparison of Sugammadex versus Neostigmine Costs and Respiratory Complications in Patients with Obstructive Sleep Apnoea." Turkish journal of anaesthesiology and reanimation vol. 43,6 (2015): 387-95. doi: https://doi.org/10.5152/TJAR.2015.35682
Ünal DY, Baran İ, Mutlu M, Ural G, Akkaya T, Özlü O. Comparison of Sugammadex versus Neostigmine Costs and Respiratory Complications in Patients with Obstructive Sleep Apnoea. Turk J Anaesthesiol Reanim. 2015 Dec;43(6):387-95. doi: 10.5152/TJAR.2015.35682. Epub 2015 Dec 01. PMID: 27366535; PMCID: PMC4894182.
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Turk J Anaesthesiol Reanim. 2015 Dec;43(6):387-95. doi: 10.5152/TJAR.2015.35682. Epub 2015 Dec 01.

Comparison of Sugammadex versus Neostigmine Costs and Respiratory Complications in Patients with Obstructive Sleep Apnoea.

Turkish journal of anaesthesiology and reanimation

Dilek Yazıcıoğlu Ünal, İlkay Baran, Murad Mutlu, Gülçin Ural, Taylan Akkaya, Onur Özlü

Affiliations

  1. Clinic of Anaesthesiology and Reanimation, Ministry Health D??kap? Y?ld?r?m Beyaz?t Training and Research Hospital, Ankara, Turkey.
  2. Clinic of Otorhinolaryngology, Ministry Health D??kap? Y?ld?r?m Beyaz?t Training and Research Hospital, Ankara, Turkey.

PMID: 27366535 PMCID: PMC4894182 DOI: 10.5152/TJAR.2015.35682

Abstract

OBJECTIVE: To compare sugammadex and neostigmine regarding the efficacy in reversing rocuronium-induced neuromuscular block, the incidence of post-operative respiratory complications and costs in patients undergoing surgery for the treatment of obstructive sleep apnoea (OSA).

METHODS: After obtaining ethical approval and patient consent, 74 patients in ASA physical status I or II were randomised into two groups to receive 2-mg kg(-1) sugammadex (Group S) or 0.04-mg kg(-1) neostigmine+0.5-mg atropine (Group N). Groups were compared regarding time to TOF (train-of-four) 0.9, operating room time, post-anaesthesia care unit (PACU) stay, post-operative respiratory complications, costs related to neuromuscular block reversal, anaesthesia care and complication treatment.

RESULTS: Patient demographics, anaesthesia, surgical data and total rocuronium doses were similar between groups. Time to TOF 0.9 was shorter for group S [Group N: 8 (5-18) min; Group S: 2 (1.5-6) min (p<0.001)]. Operating room time [Group S: 72.4±14.3 min; Group N: 96.6±22.8 min (p<0.001)] and PACU stay [Group S: 22.9±10.1 dk; Group N: 36.3±12.6 dk (p<0.001)] were also shorter in Group S. After extubation, desaturation was observed in 12 (32.4%) patients in group N and in 4 (8%) patients in group S (p=0.048). In group N, three patients were reintubated; there were eight (21.6%) unplanned intensive care unit (ICU) admissions. There was one unplanned ICU admission in group S. Negative pressure pulmonary oedema was observed in one patient in group N. The results regarding costs were as follows. The reversal cost was higher in the sugammadex group (vial cost 98.14 TL) than that in the neostigmine group (ampoule cost 0.27 TL; total 6147.88 TL vs. 3569.5 TL); however, complication treatment cost and total cost were lower in group S than those in group N (199.5 TL vs. 3944.6 TL) (staff anaesthesia doctor cost was 0.392 TL per min and the cost of nurse anaesthetist was 0.244 TL per min).

CONCLUSION: This study confirmed the efficacy of sugammadex over neostigmine for the reversal of rocuronium-induced neuromuscular block. Sugammadex decreases the incidence of post-operative respiratory complications and related costs in patients with OSA.

Keywords: Complication; cost; neostigmine; rocuronium; sugammadex

References

  1. Acta Anaesthesiol Scand. 2013 Oct;57(9):1138-45 - PubMed
  2. Acta Anaesthesiol Scand. 2007 Aug;51(7):789-808 - PubMed
  3. Sleep. 1997 Sep;20(9):705-6 - PubMed
  4. Mayo Clin Proc. 2001 Sep;76(9):897-905 - PubMed
  5. BMJ. 2004 Oct 23;329(7472):955-9 - PubMed
  6. Anesthesiology. 2006 May;104(5):1081-93; quiz 1117-8 - PubMed
  7. Anesth Analg. 2009 Mar;108(3):846-51 - PubMed
  8. Br J Anaesth. 2001 Feb;86(2):254-66 - PubMed
  9. Br J Anaesth. 2010 Nov;105(5):558-67 - PubMed
  10. Anesth Analg. 2008 Jul;107(1):130-7 - PubMed
  11. Can J Anaesth. 2009 Nov;56(11):819-28 - PubMed
  12. Anesthesiol Res Pract. 2014;2014:848051 - PubMed
  13. Core Evid. 2013;8:57-67 - PubMed
  14. Br J Anaesth. 1998 Jun;80(6):767-75 - PubMed
  15. Anesthesiology. 1995 Jan;82(1):94-101 - PubMed
  16. Chest. 2005 May;127(5):1703-9 - PubMed
  17. Anesthesiology. 2007 Oct;107(4):621-9 - PubMed
  18. Anesth Analg. 2007 Mar;104(3):575-81 - PubMed
  19. Anesth Analg. 2011 Jan;112(1):113-21 - PubMed
  20. Anesthesiology. 2013 Apr;118(4):961-78 - PubMed
  21. Anesthesiology. 2010 Apr;112(4):1013-22 - PubMed
  22. Br J Anaesth. 2012 Feb;108(2):236-9 - PubMed
  23. Anaesth Intensive Care. 2012 Mar;40(2):340-3 - PubMed
  24. Anaesthesist. 2009 Feb;58(2):180-6 - PubMed
  25. J Clin Sleep Med. 2010 Oct 15;6(5):467-72 - PubMed
  26. Br J Anaesth. 2010 Nov;105(5):568-75 - PubMed
  27. Br J Anaesth. 2000 Mar;84(3):301-3 - PubMed
  28. Anesth Analg. 2004 Jan;98(1):102-6, table of contents - PubMed

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