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Synthesis (Stuttg). 2012 Jun;44(12):1778-1791. doi: 10.1055/s-0031-1289766. Epub 2012 May 25.

Heterocycle Formation .

Synthesis

Tian-Sheng Mei, Lei Kou, Sandy Ma, Keary M Engle, Jin-Quan Yu

Affiliations

  1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037 (USA).

PMID: 27397938 PMCID: PMC4936280 DOI: 10.1055/s-0031-1289766

Abstract

Heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and agrochemicals. Therefore, the design of novel protocols to construct heterocycles more efficiently is a major area of focus in the organic chemistry. In the past several years, cyclization reactions based upon palladium-catalyzed C-H activation have received substantial attention due to their capacity for expediting heterocycle synthesis. This review discusses strategies for heterocycle synthesis

Keywords: C–H activation; Heterocycle; amination; carbonylation; olefination

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