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Strazzulla A, Coppolino G, Di Fatta C, et al. Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?. World J Hepatol. 2016;8(19):815-24doi: 10.4254/wjh.v8.i19.815.
Strazzulla, A., Coppolino, G., Di Fatta, C., Giancotti, F., D'Onofrio, G., Postorino, M. C., Mazzitelli, M., Mammone, S. V., Gentile, I., Rivoli, L., Palella, E., Gravina, T., Costa, C., Pisani, V., De Maria, V., Barreca, G. S., Marascio, N., Focà, A., Fuiano, G., Gulletta, E., & Torti, C. (2016). Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?. World journal of hepatology, 8(19), 815-24. https://doi.org/10.4254/wjh.v8.i19.815
Strazzulla, Alessio, et al. "Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?." World journal of hepatology vol. 8,19 (2016): 815-24. doi: https://doi.org/10.4254/wjh.v8.i19.815
Strazzulla A, Coppolino G, Di Fatta C, Giancotti F, D'Onofrio G, Postorino MC, Mazzitelli M, Mammone SV, Gentile I, Rivoli L, Palella E, Gravina T, Costa C, Pisani V, De Maria V, Barreca GS, Marascio N, Focà A, Fuiano G, Gulletta E, Torti C. Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?. World J Hepatol. 2016 Jul 08;8(19):815-24. doi: 10.4254/wjh.v8.i19.815. PMID: 27429717; PMCID: PMC4937169.
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World J Hepatol. 2016 Jul 08;8(19):815-24. doi: 10.4254/wjh.v8.i19.815.

Is neutrophil gelatinase associated lipocalin useful in hepatitis C virus infection?.

World journal of hepatology

Alessio Strazzulla, Giuseppe Coppolino, Concetta Di Fatta, Francesca Giancotti, Giuseppina D'Onofrio, Maria Concetta Postorino, Maria Mazzitelli, Selma Valerie Mammone, Innocenza Gentile, Laura Rivoli, Eleonora Palella, Tiziana Gravina, Chiara Costa, Vincenzo Pisani, Vincenzo De Maria, Giorgio Settimo Barreca, Nadia Marascio, Alfredo Focà, Giorgio Fuiano, Elio Gulletta, Carlo Torti

Affiliations

  1. Alessio Strazzulla, Maria Concetta Postorino, Maria Mazzitelli, Selma Valerie Mammone, Chiara Costa, Vincenzo Pisani, Carlo Torti, Infectious Diseases Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.

PMID: 27429717 PMCID: PMC4937169 DOI: 10.4254/wjh.v8.i19.815

Abstract

AIM: To evaluate neutrophil gelatinase associated lipocalin (NGAL) in patients infected by hepatitis C virus (HCV) before and during treatment with directly acting antivirals (DAAs).

METHODS: NGAL was measured in a group of patients with chronic HCV infection ranked, at baseline, by age, gender, anti-hypertensive therapy, HCV viral load, liver fibrosis stage and, either at baseline or after 1 year, estimated glomerular filtration rate (eGFR). Then, NGAL and eGFR evolutions were monitored in a subgroup of patients who started antiviral therapy with DAAs. Differences of median NGAL levels were evaluated through Wilcoxon-Mann-Whitney test for non-parametric data. Differences in dichotomous variables were evaluated through χ (2) test. At baseline, a univariate regression analysis was conducted to verify if NGAL values correlated with other quantitative variables [age, fibrosis four (FIB-4), AST to platelet ratio index (APRI), and eGFR].

RESULTS: Overall, 48 patients were enrolled, 8 of them starting HCV treatment. At baseline, statistically significant differences were found in median NGAL values only between patients with eGFR < 60 mL/min vs patients with eGFR ≥ 90 mL/min. Differences in NGAL were not significant among patients ranked by HCV viral load, FIB-4 score and APRI, when patients with NGAL > 118.11 ng/dL were compared with those of NGAL ≤ 118.11 ng/dL, not statistically significant differences were present for age, gender, chronic kidney disease classification and liver fibrosis (P > 0.05). Linear correlation was found between NGAL and both age (P = 0.0475) and eGFR (P = 0.0282) values. Not statistically significant predictions of NGAL at baseline were demonstrated for eGFR evolution 1 year later. Interestingly, in the 8 patients treated with DAAs, median NGAL significantly increased at week 12 compared to baseline (P = 0.0239).

CONCLUSION: Our results suggest that NGAL should be further evaluated as an adjunct marker of kidney function in these patients.

Keywords: Directly acting antivirals; Hepatitis C virus; Inflammation; Neutrophil gelatinase lipocalin; Tubular impairment

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