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Bhat JU, Nizami Q, Asiaf A, et al. Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice. EXCLI J. 2012;11:1-6
Bhat, J. U., Nizami, Q., Asiaf, A., Parray, S. A., Ahmad, S. T., Aslam, M., Khanam, R., Mujeeb, M., Umar, S., & Siddiqi, A. (2012). Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice. EXCLI journal, 111-6.
Bhat, Jalal Uddin, et al. "Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice." EXCLI journal vol. 11 (2012): 1-6.
Bhat JU, Nizami Q, Asiaf A, Parray SA, Ahmad ST, Aslam M, Khanam R, Mujeeb M, Umar S, Siddiqi A. Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice. EXCLI J. 2012 Jan 20;11:1-6. eCollection 2012. PMID: 27298604; PMCID: PMC4897659.
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EXCLI J. 2012 Jan 20;11:1-6. eCollection 2012.

Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice.

EXCLI journal

Jalal Uddin Bhat, Qudsia Nizami, Asia Asiaf, Shabir Ahmad Parray, Shiekh Tanveer Ahmad, Mohammad Aslam, Razia Khanam, Mohammad Mujeeb, Sadiq Umar, Ayesha Siddiqi

Affiliations

  1. Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India - 110062.
  2. Department of Biochemistry, Faculty of Science, University of Kashmir, Srinagar, J&K, India - 190006.
  3. Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India - 110062.
  4. Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi, India - 110062.
  5. Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India -110062.

PMID: 27298604 PMCID: PMC4897659

Abstract

The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.

Keywords: Melissa parviflora; anticonvulsant effects; maximal electroshock; pentylenetetrazole

References

  1. Pharmacognosy Res. 2011 Jul;3(3):194-200 - PubMed
  2. J Nat Prod. 2003 Jul;66(7):1022-37 - PubMed
  3. Neuropharmacology. 1990 Oct;29(10):943-8 - PubMed
  4. Brain Res. 1996 Oct 7;735(2):208-16 - PubMed
  5. Epilepsia. 2005 Apr;46(4):470-2 - PubMed
  6. Nat Rev Drug Discov. 2005 Mar;4(3):206-20 - PubMed
  7. Indian J Pharmacol. 2011 Feb;43(1):27-30 - PubMed
  8. Epilepsy Behav. 2006 Mar;8(2):350-62 - PubMed
  9. Phytother Res. 2003 Jan;17(1):38-43 - PubMed
  10. Epilepsia. 1997 Sep;38(9):981-90 - PubMed
  11. Toxicol Lett. 2007 Jan 30;168(2):176-85 - PubMed
  12. Antimicrob Agents Chemother. 1999 Jul;43(7):1729-36 - PubMed
  13. Seizure. 2000 Mar;9(2):96-107 - PubMed
  14. Phytomedicine. 2008 Aug;15(8):619-24 - PubMed
  15. Seizure. 2000 Dec;9(8):551-8 - PubMed

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