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Hiltunen H, Tan EC, Ilomäki J, et al. Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities. Ther Adv Drug Saf. 2016;7(3):79-88doi: 10.1177/2042098616641355.
Hiltunen, H., Tan, E. C., Ilomäki, J., Hilmer, S. N., Visvanathan, R., Emery, T., Robson, L., Jones, M. J., Hartikainen, S., & Bell, J. S. (2016). Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities. Therapeutic advances in drug safety, 7(3), 79-88. https://doi.org/10.1177/2042098616641355
Hiltunen, Henna, et al. "Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities." Therapeutic advances in drug safety vol. 7,3 (2016): 79-88. doi: https://doi.org/10.1177/2042098616641355
Hiltunen H, Tan EC, Ilomäki J, Hilmer SN, Visvanathan R, Emery T, Robson L, Jones MJ, Hartikainen S, Bell JS. Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities. Ther Adv Drug Saf. 2016 Jun;7(3):79-88. doi: 10.1177/2042098616641355. Epub 2016 Apr 01. PMID: 27298718; PMCID: PMC4892406.
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Ther Adv Drug Saf. 2016 Jun;7(3):79-88. doi: 10.1177/2042098616641355. Epub 2016 Apr 01.

Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities.

Therapeutic advances in drug safety

Henna Hiltunen, Edwin C K Tan, Jenni Ilomäki, Sarah N Hilmer, Renuka Visvanathan, Tina Emery, Leonie Robson, Mary J Jones, Sirpa Hartikainen, J Simon Bell

Affiliations

  1. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
  2. Kolling Institute of Medical Research, Sydney Medical School, Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, University of Sydney, Sydney, Australia.
  3. Adelaide Geriatrics Training and Research with Aged Care (GTRAC) Centre, School of Medicine, University of Adelaide, Adelaide, Australia.
  4. Resthaven Incorporated, Adelaide, Australia.
  5. Kuopio Research Centre of Geriatric Care, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
  6. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.

PMID: 27298718 PMCID: PMC4892406 DOI: 10.1177/2042098616641355

Abstract

OBJECTIVE: Depressive symptoms are highly prevalent in residential aged care facilities (RACFs). The prevalence of antidepressant use is increasing but the effectiveness of antidepressants in people with dementia is uncertain. The objective of the study was to investigate factors associated with antidepressant use in residents with and without dementia.

METHODS: This was a prospective cross-sectional study of 383 residents in six Australian RACFs. Data on health status, medications and demographics were collected by trained study nurses from April to August 2014. Logistic regression was used to compute adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for factors associated with antidepressant use. Analyses were stratified by dementia and depression.

RESULTS: Overall, 183 (47.8%) residents used antidepressants. The prevalence of antidepressant use was similar among residents with and without dementia. Clinician-observed pain was inversely associated with antidepressant use in the main analysis (AOR = 0.56, 95% CI = 0.32-0.99) and in subanalyses for residents with documented depression (AOR = 0.51, 95% CI = 0.27-0.96). In residents with dementia, moderate quality of life was associated with a lower odds of antidepressant use compared with poor quality of life (AOR = 0.35, 95% C I= 0.13-0.95). In residents without dementia, analgesic use was associated with antidepressant use (AOR = 2.34, 95% CI = 1.07-5.18).

CONCLUSIONS: The prevalence of antidepressant use was similar in residents with and without dementia. Clinician-observed pain was inversely associated with antidepressant use but there was no association between self-reported pain and antidepressant use.

Keywords: antidepressants; dementia; depression; homes for the aged; pain

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