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Roy T, Thangaraj M, Gonnade RG, et al. Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes. Chem Commun (Camb). 2016;52(58):9044-7doi: 10.1039/c6cc00057f.
Roy, T., Thangaraj, M., Gonnade, R. G., & Biju, A. T. (2016). Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes. Chemical communications (Cambridge, England), 52(58), 9044-7. https://doi.org/10.1039/c6cc00057f
Roy, Tony, et al. "Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes." Chemical communications (Cambridge, England) vol. 52,58 (2016): 9044-7. doi: https://doi.org/10.1039/c6cc00057f
Roy T, Thangaraj M, Gonnade RG, Biju AT. Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes. Chem Commun (Camb). 2016 Jul 12;52(58):9044-7. doi: 10.1039/c6cc00057f. PMID: 27400886.
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Chem Commun (Camb). 2016 Jul 12;52(58):9044-7. doi: 10.1039/c6cc00057f.

Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes.

Chemical communications (Cambridge, England)

Tony Roy, Manikandan Thangaraj, Rajesh G Gonnade, Akkattu T Biju

Affiliations

  1. Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. [email protected].
  2. Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India.

PMID: 27400886 DOI: 10.1039/c6cc00057f

Abstract

A transition-metal-free three-component coupling involving N-substituted aziridines, arynes and aldehydes resulting in the formation of trisubstituted N-aryl α-amino epoxides has been demonstrated. The reaction likely proceeds via the highly strained cyclic nitrogen ylide intermediates generated from aziridines and arynes.

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