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Shimada Y, Horiguchi M. Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes. Neuroophthalmology. 2016;40(3):125-129doi: 10.3109/01658107.2016.1148744.
Shimada, Y., & Horiguchi, M. (2016). Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes. Neuro-ophthalmology (Aeolus Press), 40(3), 125-129. https://doi.org/10.3109/01658107.2016.1148744
Shimada, Yoshiaki, and Horiguchi, Masayuki. "Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes." Neuro-ophthalmology (Aeolus Press) vol. 40,3 (2016): 125-129. doi: https://doi.org/10.3109/01658107.2016.1148744
Shimada Y, Horiguchi M. Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes. Neuroophthalmology. 2016 May 03;40(3):125-129. doi: 10.3109/01658107.2016.1148744. Epub 2016 Mar 09. PMID: 27335507; PMCID: PMC4898147.
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Neuroophthalmology. 2016 May 03;40(3):125-129. doi: 10.3109/01658107.2016.1148744. Epub 2016 Mar 09.

Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes.

Neuro-ophthalmology (Aeolus Press)

Yoshiaki Shimada, Masayuki Horiguchi

Affiliations

  1. Department of Ophthalmology, Fujita Health University Hospital , Aichi, Japan.

PMID: 27335507 PMCID: PMC4898147 DOI: 10.3109/01658107.2016.1148744

Abstract

Leber hereditary optic neuropathy (LHON) causes visual loss, predominantly in healthy young men. We recently examined a patient who previously had bilateral macular holes and subsequently developed LHON at 74 years of age. Although his central scotomas were initially attributed to the macular holes, his visual acuity declined following an initial improvement after operative closure of the macular holes; thus, other diagnoses, including LHON, were considered. Furthermore, macular optical coherence tomography (OCT) images remained unchanged in this time. A mitochondrial genetic analysis identified a 11778G→A mutation. From this case, we propose that LHON remains in the differential diagnosis even in older patients, as has previously been reported.

Keywords: Central scotoma; Leberhereditary optic neuropathy; macular hole

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