ISRN Mol Biol. 2012 Oct 17;2012:856987. doi: 10.5402/2012/856987. eCollection 2012.
ISRN molecular biology
Ann Louise Olson
PMID: 27335671 PMCID: PMC4890881 DOI: 10.5402/2012/856987
GLUT4 has long been known to be an insulin responsive glucose transporter. Regulation of GLUT4 has been a major focus of research on the cause and prevention of type 2 diabetes. Understanding how insulin signaling alters the intracellular trafficking of GLUT4 as well as understanding the fate of glucose transported into the cell by GLUT4 will be critically important for seeking solutions to the current rise in diabetes and metabolic disease.