Display options
Share it on

ISRN Mol Biol. 2012 Oct 17;2012:856987. doi: 10.5402/2012/856987. eCollection 2012.

Regulation of GLUT4 and Insulin-Dependent Glucose Flux.

ISRN molecular biology

Ann Louise Olson

Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, BMSB 964, Oklahoma City, OK 73190, USA.

PMID: 27335671 PMCID: PMC4890881 DOI: 10.5402/2012/856987

Abstract

GLUT4 has long been known to be an insulin responsive glucose transporter. Regulation of GLUT4 has been a major focus of research on the cause and prevention of type 2 diabetes. Understanding how insulin signaling alters the intracellular trafficking of GLUT4 as well as understanding the fate of glucose transported into the cell by GLUT4 will be critically important for seeking solutions to the current rise in diabetes and metabolic disease.

References

  1. Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17 - PubMed
  2. J Biol Chem. 1991 Jul 5;266(19):12690-4 - PubMed
  3. Mol Cell Biol. 2002 Sep;22(17):6247-60 - PubMed
  4. Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1149-56 - PubMed
  5. J Biol Chem. 1998 Jul 10;273(28):17504-10 - PubMed
  6. J Cell Biol. 2008 Jan 28;180(2):375-87 - PubMed
  7. Diabetes. 1992 Sep;41(9):1091-9 - PubMed
  8. Mol Cell Biol. 2007 May;27(9):3456-69 - PubMed
  9. J Neuroendocrinol. 2011 Dec;23(12):1288-95 - PubMed
  10. Diabetes. 1984 Jul;33(7):622-6 - PubMed
  11. J Cell Biol. 2011 Apr 4;193(1):185-99 - PubMed
  12. J Clin Endocrinol Metab. 2009 Sep;94(9):3535-42 - PubMed
  13. J Biol Chem. 1993 Jul 5;268(19):13824-9 - PubMed
  14. Cell. 1989 Apr 21;57(2):305-15 - PubMed
  15. Diabetes. 2012 Jun;61(6):1404-14 - PubMed
  16. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E739-43 - PubMed
  17. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11346-50 - PubMed
  18. Proc Natl Acad Sci U S A. 1980 May;77(5):2542-5 - PubMed
  19. Cell Metab. 2007 Apr;5(4):293-303 - PubMed
  20. J Biol Chem. 2004 Dec 3;279(49):50956-61 - PubMed
  21. J Biol Chem. 1998 Oct 2;273(40):26157-63 - PubMed
  22. Biochem Soc Trans. 2005 Apr;33(Pt 2):346-9 - PubMed
  23. Nature. 1995 Sep 14;377(6545):151-5 - PubMed
  24. Biochem Soc Trans. 2004 Nov;32(Pt 5):817-21 - PubMed
  25. Cell Metab. 2007 Jan;5(1):47-57 - PubMed
  26. J Cell Biol. 1996 Aug;134(3):625-35 - PubMed
  27. Am J Physiol. 1996 Apr;270(4 Pt 2):R785-92 - PubMed
  28. Biochem J. 1995 Apr 15;307 ( Pt 2):383-90 - PubMed
  29. Endocr Rev. 1995 Apr;16(2):117-42 - PubMed
  30. Science. 2001 Jun 1;292(5522):1728-31 - PubMed
  31. J Biol Chem. 1993 Oct 25;268(30):22243-6 - PubMed
  32. Diabetes. 2011 May;60(5):1478-82 - PubMed
  33. Science. 2005 Feb 18;307(5712):1098-101 - PubMed
  34. Mol Biol Cell. 2002 Jul;13(7):2421-35 - PubMed
  35. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1148-54 - PubMed
  36. J Biol Chem. 1993 Oct 5;268(28):21021-7 - PubMed
  37. J Biol Chem. 1998 Mar 13;273(11):6210-7 - PubMed
  38. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5817-21 - PubMed
  39. Biochem J. 1996 Apr 15;315 ( Pt 2):487-95 - PubMed
  40. Diabetes. 2008 Apr;57(4):860-7 - PubMed
  41. Mol Biol Cell. 1999 May;10(5):1581-94 - PubMed
  42. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E92-100 - PubMed
  43. J Clin Invest. 1999 Dec;104(12):1703-14 - PubMed
  44. Nature. 1989 Jul 6;340(6228):70-2 - PubMed
  45. Front Biosci. 2003 May 01;8:s401-9 - PubMed
  46. Diabetes. 1981 Dec;30(12):1000-7 - PubMed
  47. J Biol Chem. 2002 Jun 21;277(25):22115-8 - PubMed
  48. Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E187-96 - PubMed
  49. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E733-8 - PubMed
  50. J Biol Chem. 1998 Aug 14;273(33):20910-5 - PubMed
  51. Am J Physiol. 1992 Jan;262(1 Pt 1):C9-14 - PubMed
  52. J Biol Chem. 1990 May 15;265(14):7994-8000 - PubMed
  53. J Biol Chem. 1992 Mar 5;267(7):4957-62 - PubMed
  54. J Nutr. 1994 Aug;124(8 Suppl):1289S-1295S - PubMed
  55. J Biol Chem. 1989 Jun 15;264(17):9885-90 - PubMed
  56. Cell. 2011 Mar 4;144(5):757-68 - PubMed
  57. Diabetes. 1996 Jan;45(1):28-36 - PubMed
  58. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3096-9 - PubMed
  59. Am J Physiol. 1999 Feb;276(2 Pt 1):E390-400 - PubMed
  60. J Biol Chem. 2000 Aug 4;275(31):23666-73 - PubMed
  61. Nature. 1989 Mar 2;338(6210):83-7 - PubMed
  62. J Clin Invest. 1995 Apr;95(4):1512-8 - PubMed
  63. Mol Biol Cell. 2001 Nov;12(11):3489-501 - PubMed
  64. J Cell Biol. 1991 Apr;113(1):123-35 - PubMed
  65. J Appl Physiol (1985). 1997 Dec;83(6):2043-7 - PubMed
  66. EMBO J. 1992 Sep;11(9):3469-79 - PubMed
  67. Endocrinology. 1995 May;136(5):1962-8 - PubMed
  68. Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94 - PubMed
  69. Diabetes. 2010 Jun;59(6):1397-406 - PubMed
  70. J Biol Chem. 1993 May 5;268(13):9839-46 - PubMed
  71. J Biol Chem. 1992 Jun 15;267(17):11673-6 - PubMed
  72. Nature. 1998 Feb 26;391(6670):900-4 - PubMed
  73. J Cell Biol. 1992 Jun;117(6):1181-96 - PubMed
  74. FASEB J. 1999 Dec;13(15):2246-56 - PubMed
  75. J Biol Chem. 1976 Feb 10;251(3):794-800 - PubMed
  76. J Biol Chem. 1993 May 5;268(13):9187-90 - PubMed
  77. Nature. 2003 Oct 16;425(6959):727-33 - PubMed
  78. J Biol Chem. 2000 Aug 18;275(33):25494-501 - PubMed
  79. J Exp Biol. 2011 Jan 15;214(Pt 2):254-62 - PubMed
  80. J Biol Chem. 1994 Nov 25;269(47):29956-61 - PubMed
  81. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2535-9 - PubMed
  82. Nature. 2001 Dec 13;414(6865):799-806 - PubMed
  83. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14725-30 - PubMed
  84. J Biol Chem. 1993 Mar 5;268(7):4600-3 - PubMed
  85. J Biol Chem. 2005 Dec 9;280(49):40406-16 - PubMed
  86. J Physiol Pharmacol. 2008 Dec;59 Suppl 7:5-18 - PubMed
  87. Eur J Biochem. 1999 Oct 1;265(1):353-60 - PubMed
  88. EMBO J. 2003 May 15;22(10 ):2387-99 - PubMed
  89. Am J Physiol. 1990 Dec;259(6 Pt 1):C279-85 - PubMed
  90. Am J Physiol. 1994 Feb;266(2 Pt 1):E171-8 - PubMed
  91. Biochem J. 2008 Apr 1;411(1):89-95 - PubMed
  92. J Biol Chem. 1994 Jul 1;269(26):17516-24 - PubMed
  93. J Biol Chem. 2006 Dec 22;281(51):39719-27 - PubMed
  94. J Biol Chem. 1994 Nov 11;269(45):28514-21 - PubMed
  95. FASEB J. 2006 Feb;20(2):348-9 - PubMed
  96. Traffic. 2000 Feb;1(2):141-51 - PubMed
  97. Endocrinology. 1992 Feb;130(2):837-46 - PubMed
  98. J Biol Chem. 1980 May 25;255(10):4758-62 - PubMed
  99. J Clin Invest. 2005 Feb;115(2):219-21 - PubMed
  100. J Biol Chem. 2008 Mar 21;283(12):7429-37 - PubMed
  101. Diabetes. 2001 Mar;50(3):593-600 - PubMed
  102. J Biol Chem. 1994 May 20;269(20):14396-401 - PubMed
  103. Mol Cell Biol. 2000 Jan;20(1):416-27 - PubMed
  104. J Physiol. 2009 Dec 15;587(Pt 24):5951-8 - PubMed
  105. FEBS J. 2012 Feb;279(4):599-611 - PubMed
  106. J Biol Chem. 1995 Oct 6;270(40):23491-5 - PubMed
  107. Diabetes. 1996 Jan;45(1):23-7 - PubMed
  108. Mol Med. 2004 Jul-Dec;10(7-12):65-71 - PubMed
  109. Recent Prog Horm Res. 1998;53:119-38 - PubMed
  110. J Biol Chem. 1996 Dec 6;271(49):31372-8 - PubMed
  111. Nature. 1988 May 12;333(6169):183-5 - PubMed
  112. J Biol Chem. 1993 Jan 5;268(1):640-4 - PubMed
  113. J Biol Chem. 2003 Apr 25;278(17 ):14599-602 - PubMed
  114. J Biol Chem. 1999 Jan 22;274(4):1865-8 - PubMed
  115. J Cell Biol. 2012 Aug 20;198(4):545-60 - PubMed
  116. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7815-9 - PubMed
  117. Cell. 1988 Oct 21;55(2):281-90 - PubMed
  118. J Biol Chem. 2003 Jun 13;278(24):21615-22 - PubMed
  119. Nature. 2001 Feb 8;409(6821):729-33 - PubMed
  120. J Biol Chem. 2011 Jan 7;286(1):460-8 - PubMed
  121. J Biol Chem. 1990 Aug 15;265(23):13801-8 - PubMed
  122. J Clin Invest. 1991 Mar;87(3):1072-81 - PubMed
  123. Can J Physiol Pharmacol. 1992 Sep;70(9):1286-90 - PubMed
  124. Mol Cell Biol. 1994 Jun;14(6):3577-87 - PubMed
  125. J Biol Chem. 2002 Mar 15;277(11):9133-8 - PubMed
  126. Endocrinology. 1997 Apr;138(4):1604-11 - PubMed
  127. J Biol Chem. 1998 Jun 5;273(23):14285-92 - PubMed
  128. J Cell Biol. 2005 May 9;169(3):481-9 - PubMed
  129. Nature. 2012 Apr 19;484(7394):333-8 - PubMed
  130. Nat Rev Mol Cell Biol. 2002 Apr;3(4):267-77 - PubMed
  131. J Biol Chem. 2005 Nov 11;280(45):37803-13 - PubMed
  132. Diabetologia. 1977 Apr;13(2):93-7 - PubMed
  133. Mol Biol Cell. 2003 Mar;14(3):973-86 - PubMed
  134. Diabetes. 2005 Mar;54(3):603-8 - PubMed
  135. J Appl Physiol (1985). 1998 Mar;84(3):798-802 - PubMed
  136. J Clin Invest. 1997 Aug 1;100(3):671-7 - PubMed
  137. Nature. 1989 Jul 6;340(6228):72-4 - PubMed
  138. Nat Med. 2000 Aug;6(8):924-8 - PubMed
  139. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  140. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H976-82 - PubMed

Publication Types