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Sorto-Gomez TE, Ortiz GG, Pacheco-Moises FP, et al. Effect of fish oil on glutathione redox system in multiple sclerosis. Am J Neurodegener Dis. 2016;5(2):145-51
Sorto-Gomez, T. E., Ortiz, G. G., Pacheco-Moises, F. P., Torres-Sanchez, E. D., Ramirez-Ramirez, V., Macias-Islas, M. A., de la Rosa, A. C., & Velázquez-Brizuela, I. E. (2016). Effect of fish oil on glutathione redox system in multiple sclerosis. American journal of neurodegenerative disease, 5(2), 145-51.
Sorto-Gomez, Tania E, et al. "Effect of fish oil on glutathione redox system in multiple sclerosis." American journal of neurodegenerative disease vol. 5,2 (2016): 145-51.
Sorto-Gomez TE, Ortiz GG, Pacheco-Moises FP, Torres-Sanchez ED, Ramirez-Ramirez V, Macias-Islas MA, de la Rosa AC, Velázquez-Brizuela IE. Effect of fish oil on glutathione redox system in multiple sclerosis. Am J Neurodegener Dis. 2016 Jun 01;5(2):145-51. eCollection 2016. PMID: 27335704; PMCID: PMC4913222.
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Am J Neurodegener Dis. 2016 Jun 01;5(2):145-51. eCollection 2016.

Effect of fish oil on glutathione redox system in multiple sclerosis.

American journal of neurodegenerative disease

Tania E Sorto-Gomez, Genaro G Ortiz, Fermín P Pacheco-Moises, Erandis D Torres-Sanchez, Viridiana Ramirez-Ramirez, Miguel A Macias-Islas, Alfredo Celis de la Rosa, Irma E Velázquez-Brizuela

Affiliations

  1. Laboratorio de Mitocondria-Estrés Oxidativo & Patología, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS) Sierra Mojada 800, 44340 Guadalajara, Jalisco, México.
  2. Laboratorio de Bioquímica, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara Guadalajara, JAL, México.
  3. Departamento de Neurología, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico de Nacional de Occidente (CMNO) IMSS, Guadalajara, Jalisco, México.
  4. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara Guadalajara, Jalisco, México.
  5. OPD Instituto Jalisciense de Cancerología SSA-Jalisco. Guadalajara, Jalisco. México.

PMID: 27335704 PMCID: PMC4913222

Abstract

UNLABELLED: Multiple sclerosis (MS) is a chronic, inflammatory and autoimmune disease of the central nervous system. Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme activities are implicated in the induction and progression of MS. Evidence suggests that Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory, antioxidant and neuroprotective effects. The aim of the present work was to evaluate the effect of fish oil on the activity of glutathione reductase (GR), content of reduced and oxidized glutathione, and GSH/GSSG ratio in MS. 50 patients with relapsing-remitting MS were enrolled. The experimental group received orally 4 g/day of fish oil for 12 months. Fish oil supplementation resulted in a significant increase in n-3 fatty acids and a decrease n-6 fatty acids. No differences in glutathione reductase activity, content of reduced and oxidized glutathione, and GSH/GSSG ratio were found.

CONCLUSION: Glutathione reductase activity was not significantly different between the groups; however, fish oil supplementation resulted in smaller increase in GR compared with control group, suggesting a possible effect on antioxidant defence mechanisms.

Keywords: Fish oil; glutathion; multiple sclerosis

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