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Ito E, Nakano S, Otsuka M, et al. Spontaneous breast cancer remission: A case report. Int J Surg Case Rep. 2016;25:132-6doi: 10.1016/j.ijscr.2016.06.017.
Ito, E., Nakano, S., Otsuka, M., Mibu, A., Karikomi, M., Oinuma, T., & Yamamoto, M. (2016). Spontaneous breast cancer remission: A case report. International journal of surgery case reports, 25132-6. https://doi.org/10.1016/j.ijscr.2016.06.017
Ito, Eisaku, et al. "Spontaneous breast cancer remission: A case report." International journal of surgery case reports vol. 25 (2016): 132-6. doi: https://doi.org/10.1016/j.ijscr.2016.06.017
Ito E, Nakano S, Otsuka M, Mibu A, Karikomi M, Oinuma T, Yamamoto M. Spontaneous breast cancer remission: A case report. Int J Surg Case Rep. 2016;25:132-6. doi: 10.1016/j.ijscr.2016.06.017. Epub 2016 Jun 25. PMID: 27372025; PMCID: PMC4929343.
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Int J Surg Case Rep. 2016;25:132-6. doi: 10.1016/j.ijscr.2016.06.017. Epub 2016 Jun 25.

Spontaneous breast cancer remission: A case report.

International journal of surgery case reports

Eisaku Ito, Satoko Nakano, Masahiko Otsuka, Akemi Mibu, Masahito Karikomi, Toshinori Oinuma, Masahiro Yamamoto

Affiliations

  1. Department of Surgery, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].
  2. Department of Surgery, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].
  3. Department of Surgery, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].
  4. Department of Laboratory, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].
  5. Department of Radiology, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].
  6. Department of Pathology, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan.
  7. Department of Pathology, Kawaguchi Municipal Medical Center, 180 Nishi-Araijyuku, Kawaguchi City, Saitama, 333-0833, Japan. Electronic address: [email protected].

PMID: 27372025 PMCID: PMC4929343 DOI: 10.1016/j.ijscr.2016.06.017

Abstract

INTRODUCTION: Spontaneous breast cancer remission is a rare phenomenon. We report the disappearance from the remaining breast of a new primary carcinoma that had been confirmed through cytology of a pathological specimen, in a case that is strongly suspected to be spontaneous remission.

PRESENTATION OF CASE: A 44-year-old woman underwent breast-conserving surgery for a tumor located on the border between the upper-outer and lower-outer quadrants of the left breast (T2, N1, M0; Stage IIB). Eleven years after surgery, computed tomography indicated a mass in the upper-inner quadrant of the left breast. Excisional biopsy was initially planned for treatment following the definitive diagnosis because cytology revealed malignancy. The patient had noticed tumor regression one month after fine-needle aspiration and repeat ultrasonography performed the day before excisional biopsy confirmed the tumor reduction. On pathological examination, no tumor cells were observed in the mass.

DISCUSSION: There was a discrepancy between FNA cytology and pathological diagnosis in our patient. The cytological findings indicated malignancy, but the pathological findings did not. When a tumor's pathological diagnosis is not malignant even though its FNA cytology diagnosis was malignant, sampling error, cytological over-diagnosis or some other error may have occurred. In this case, however, these were not detected. Because fibrosis was visible on pathological examination, we believe that these events corresponded to spontaneous remission.

CONCLUSION: We report a rare case of spontaneous remission in which the cancer disappeared on pathological examination although the cytological diagnosis had been malignant.

Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: Breast cancer; Healing carcinoma; Spontaneous cancer remission

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