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Udukala DN, Wang H, Wendel SO, et al. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection. Beilstein J Nanotechnol. 2016;7:364-373doi: 10.3762/bjnano.7.33.
Udukala, D. N., Wang, H., Wendel, S. O., Malalasekera, A. P., Samarakoon, T. N., Yapa, A. S., Abayaweera, G., Basel, M. T., Maynez, P., Ortega, R., Toledo, Y., Bossmann, L., Robinson, C., Janik, K. E., Koper, O. B., Li, P., Motamedi, M., Higgins, D. A., Gadbury, G., Zhu, G., Troyer, D. L., & Bossmann, S. H. (2016). Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection. Beilstein journal of nanotechnology, 7364-373. https://doi.org/10.3762/bjnano.7.33
Udukala, Dinusha N, et al. "Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection." Beilstein journal of nanotechnology vol. 7 (2016): 364-373. doi: https://doi.org/10.3762/bjnano.7.33
Udukala DN, Wang H, Wendel SO, Malalasekera AP, Samarakoon TN, Yapa AS, Abayaweera G, Basel MT, Maynez P, Ortega R, Toledo Y, Bossmann L, Robinson C, Janik KE, Koper OB, Li P, Motamedi M, Higgins DA, Gadbury G, Zhu G, Troyer DL, Bossmann SH. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection. Beilstein J Nanotechnol. 2016 Mar 07;7:364-373. doi: 10.3762/bjnano.7.33. eCollection 2016. PMID: 27335730; PMCID: PMC4901534.
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Beilstein J Nanotechnol. 2016 Mar 07;7:364-373. doi: 10.3762/bjnano.7.33. eCollection 2016.

Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection.

Beilstein journal of nanotechnology

Dinusha N Udukala, Hongwang Wang, Sebastian O Wendel, Aruni P Malalasekera, Thilani N Samarakoon, Asanka S Yapa, Gayani Abayaweera, Matthew T Basel, Pamela Maynez, Raquel Ortega, Yubisela Toledo, Leonie Bossmann, Colette Robinson, Katharine E Janik, Olga B Koper, Ping Li, Massoud Motamedi, Daniel A Higgins, Gary Gadbury, Gaohong Zhu, Deryl L Troyer, Stefan H Bossmann

Affiliations

  1. Kansas State University, Department of Chemistry, 213 CBC Building, Manhattan, KS, USA.
  2. Kansas State University, Department of Anatomy & Physiology, 228 Coles Hall, Manhattan, KS, USA.
  3. The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA.
  4. Kansas State University, Department of Statistics, 101 Dickens Hall, Manhattan, KS, USA.
  5. The First Affiliated Hospital of Kunming Medical University, Department of Nuclear Medicine, 295 Xichang Road, Kunming, Yunnan, PR China.

PMID: 27335730 PMCID: PMC4901534 DOI: 10.3762/bjnano.7.33

Abstract

Proteases, including matrix metalloproteinases (MMPs), tissue serine proteases, and cathepsins (CTS) exhibit numerous functions in tumor biology. Solid tumors are characterized by changes in protease expression levels by tumor and surrounding tissue. Therefore, monitoring protease levels in tissue samples and liquid biopsies is a vital strategy for early cancer detection. Water-dispersable Fe/Fe3O4-core/shell based nanoplatforms for protease detection are capable of detecting protease activity down to sub-femtomolar limits of detection. They feature one dye (tetrakis(carboxyphenyl)porphyrin (TCPP)) that is tethered to the central nanoparticle by means of a protease-cleavable consensus sequence and a second dye (Cy 5.5) that is directly linked. Based on the protease activities of urokinase plasminogen activator (uPA), MMPs 1, 2, 3, 7, 9, and 13, as well as CTS B and L, human breast cancer can be detected at stage I by means of a simple serum test. By monitoring CTS B and L stage 0 detection may be achieved. This initial study, comprised of 46 breast cancer patients and 20 apparently healthy human subjects, demonstrates the feasibility of protease-activity-based liquid biopsies for early cancer diagnosis.

Keywords: biophotonics; breast cancer; iron/iron oxide nanoparticle; liquid biopsy; nanodiagnostics detection; nanomedicine; sub-femtomolar limit of detection

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