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Shukla G, Singh S, Verma A. Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice. ISRN Parasitol. 2013;2013:762638doi: 10.5402/2013/762638.
Shukla, G., Singh, S., & Verma, A. (2013). Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice. ISRN parasitology, 2013762638. https://doi.org/10.5402/2013/762638
Shukla, Geeta, et al. "Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice." ISRN parasitology vol. 2013 (2013): 762638. doi: https://doi.org/10.5402/2013/762638
Shukla G, Singh S, Verma A. Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice. ISRN Parasitol. 2013 Sep 21;2013:762638. doi: 10.5402/2013/762638. eCollection 2013. PMID: 27335861; PMCID: PMC4890930.
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ISRN Parasitol. 2013 Sep 21;2013:762638. doi: 10.5402/2013/762638. eCollection 2013.

Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice.

ISRN parasitology

Geeta Shukla, Sumedha Singh, Angela Verma

Affiliations

  1. Department of Microbiology, Basic Medical Sciences, Panjab University, Chandigarh 160014, India.

PMID: 27335861 PMCID: PMC4890930 DOI: 10.5402/2013/762638

Abstract

Malnutrition reduces the host immunity and enhances the host susceptibility to various diseases. The present study describes the effect of oral administration of probiotic Lactobacillus casei to malnourished-Giardia-infected BALB/c mice with respect to surface alterations and brush border membrane enzyme activity of the small intestine. It was observed that probiotic feeding either prior to or simultaneously with Giardia infection to malnourished mice led to significantly enhanced activity of disaccharidases compared with malnourished and Giardia-infected mice. Scanning electron microscopy also revealed less mucosal damage in the villi of small intestine of probiotic-fed malnourished-Giardia-infected mice compared with completely damaged, mummified, or blunted villi of malnourished-Giardia-infected mice. The findings indicate that probiotics can be used as the prophylactic candidate in abrogating the gut and intestinal dissacharidases anamolies in malnourished hosts suffering from the intestinal diseases.

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