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Jung MC, Shin MK, Hong KK, et al. Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB. Ann Dermatol. 2008;20(3):113-9doi: 10.5021/ad.2008.20.3.113.
Jung, M. C., Shin, M. K., Hong, K. K., Jeong, K. H., & Kim, N. I. (2008). Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB. Annals of dermatology, 20(3), 113-9. https://doi.org/10.5021/ad.2008.20.3.113
Jung, Moon Chul, et al. "Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB." Annals of dermatology vol. 20,3 (2008): 113-9. doi: https://doi.org/10.5021/ad.2008.20.3.113
Jung MC, Shin MK, Hong KK, Jeong KH, Kim NI. Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB. Ann Dermatol. 2008 Sep;20(3):113-9. doi: 10.5021/ad.2008.20.3.113. Epub 2008 Sep 30. PMID: 27303173; PMCID: PMC4903960.
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Ann Dermatol. 2008 Sep;20(3):113-9. doi: 10.5021/ad.2008.20.3.113. Epub 2008 Sep 30.

Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB.

Annals of dermatology

Moon Chul Jung, Min Kyung Shin, Kyung Kook Hong, Ki Heon Jeong, Nack In Kim

Affiliations

  1. Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

PMID: 27303173 PMCID: PMC4903960 DOI: 10.5021/ad.2008.20.3.113

Abstract

BACKGROUND: Transforming growth factor-β (TGF-β), a multifunctional growth factor, has three isoforms: TGF-β1, TGF-β2, and TGF-β3. Different isoforms of TGF-β are associated with different proliferation and differentiation states of the epidermis. Narrow band ultraviolet B (NBUVB) emits a concentrated UVB source of 311 nm. NBUVB 1,000 mJ/cm(2) induces apoptosis in approximately 50% of keratinocytes.

OBJECTIVE: The purpose of this study was to evaluate whether irradiation with NBUVB would alter the expression and production of TGF-β1, 2, and 3.

METHODS: We measured TGF-β1, 2, and 3 mRNA and TGF-β1 and 2 protein levels at 800, 1,000, and 1,200 mJ/cm(2) for 24 hours and 48 hours.

RESULTS: TGF-β1 mRNA levels were increased at both 24 hr and 48 hr, TGF-β2 mRNA levels were decreased at both 24 hr and 48 hr, and TGF-β3 mRNA levels were increased at 24 hr and similar to control at 48 hr. TGF-β1 protein levels were increased at 48 hr but decreased at 24 hr. TGF-β2 protein levels were decreased at both 24 hr and 48 hr.

CONCLUSION: The results suggest a possible role for TGF-β1 after NBUVB irradiation and opposing roles for TGF-β1 and TGF-β2 isoforms in NBUVB irradiation.

Keywords: Keratinocytes; NBUVB; Transforming growth factor β (TGF-β)

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