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Boulter DJ, Rosado-de-Christenson ML, Stevens R, et al. Primary Synovial Sarcoma of the Lung. Radiol Case Rep. 2015;2(4):82doi: 10.2484/rcr.v2i4.82.
Boulter, D. J., Rosado-de-Christenson, M. L., Stevens, R., & Suster, S. (2007). Primary Synovial Sarcoma of the Lung. Radiology case reports, 2(4), 82. https://doi.org/10.2484/rcr.v2i4.82
Boulter, Daniel J, et al. "Primary Synovial Sarcoma of the Lung." Radiology case reports vol. 2,4 (2007): 82. doi: https://doi.org/10.2484/rcr.v2i4.82
Boulter DJ, Rosado-de-Christenson ML, Stevens R, Suster S. Primary Synovial Sarcoma of the Lung. Radiol Case Rep. 2015 Dec 07;2(4):82. doi: 10.2484/rcr.v2i4.82. eCollection 2007. PMID: 27303489; PMCID: PMC4895772.
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Radiol Case Rep. 2015 Dec 07;2(4):82. doi: 10.2484/rcr.v2i4.82. eCollection 2007.

Primary Synovial Sarcoma of the Lung.

Radiology case reports

Daniel J Boulter, Melissa L Rosado-de-Christenson, Robert Stevens, Saul Suster

PMID: 27303489 PMCID: PMC4895772 DOI: 10.2484/rcr.v2i4.82

Abstract

We describe a case of primary pulmonary synovial sarcoma. A 19-year-old man presented with low-grade fever, dyspnea, chest pain and left arm numbness. Chest radiographs revealed a large, well-circumscribed left perihilar mass and a small ipsilateral pleural effusion. Chest computed tomography (CT) revealed a large well-defined, heterogeneous lung mass. Magnetic resonance imaging (MRI) demonstrated a mass of heterogeneous signal intensity on T1-weighted and proton density images, and high signal intensity on short tau inversion recovery (STIR) images. Whole-body bone scintigraphy showed no evidence of skeletal involvement. Abdominal and pelvic CT showed no intra-abominal or pelvic metastases. A CT-guided biopsy provided the diagnosis of monophasic synovial sarcoma. Following four cycles of chemotherapy, integrated F-18 fluorodeoxyglucose positron emission tomography-computed tomography (18F FDG PET/CT) was performed, which demonstrated interval decrease in the size of the lesion and no significant metabolic activity. Surgical resection was then undertaken. Microscopically, the lesion was a high-grade spindle cell sarcoma consistent with monophasic synovial sarcoma. A variant X;18 translocation was identified by cytogenetic analysis and confirmed with metaphase in situ hybridization. The imaging and pathological features of this rare lesion are reviewed.

Keywords: CT, computed tomography

References

  1. Am J Clin Pathol. 1999 Jul;112(1):43-9 - PubMed
  2. Radiographics. 2006 May-Jun;26(3):923-40 - PubMed
  3. Hum Pathol. 1995 May;26(5):474-80 - PubMed
  4. Arch Pathol Lab Med. 2005 Aug;129(8):1063-4 - PubMed
  5. N Engl J Med. 1998 Jan 15;338(3):153-60 - PubMed
  6. Pathol Res Pract. 2003;199(12):827-33 - PubMed
  7. Radiat Med. 2005 May;23 (3):208-12 - PubMed
  8. Mod Pathol. 1999 Dec;12(12):1124-31 - PubMed
  9. J Pediatr Hematol Oncol. 2005 Apr;27(4):207-11 - PubMed
  10. Am J Surg Pathol. 1996 Jan;20(1):36-45 - PubMed
  11. AJR Am J Roentgenol. 1989 Sep;153(3):541-7 - PubMed
  12. AJR Am J Roentgenol. 1993 Oct;161(4):827-30 - PubMed
  13. Jpn J Clin Oncol. 2005 May;35(5):274-9 - PubMed
  14. Cancer Genet Cytogenet. 1996 May;88(1):49-52 - PubMed
  15. Intern Med. 2006;45(10):679-83 - PubMed
  16. Cancer. 1965 May;18:613-27 - PubMed
  17. Hum Pathol. 1986 Oct;17(10):996-1008 - PubMed
  18. Magn Reson Imaging. 1989 Mar-Apr;7(2):211-6 - PubMed
  19. Cancer. 2002 Jan 15;94(2):459-69 - PubMed
  20. Am J Surg Pathol. 2005 Mar;29(3):339-46 - PubMed
  21. Hum Pathol. 2004 Jul;35(7):850-6 - PubMed
  22. Acta Cytol. 2005 Nov-Dec;49(6):673-6 - PubMed
  23. Am J Surg Pathol. 2001 Jun;25(6):776-81 - PubMed
  24. J Thorac Imaging. 2003 Apr;18(2):87-93 - PubMed
  25. Radiographics. 2002 May-Jun;22(3):621-37 - PubMed
  26. AJR Am J Roentgenol. 1991 Feb;156(2):337-40 - PubMed
  27. Clin Imaging. 2006 Jan-Feb;30(1):60-2 - PubMed
  28. Lung Cancer. 2002 Dec;38(3):283-9 - PubMed
  29. Ultrastruct Pathol. 1991 Jul-Oct;15(4-5):379-402 - PubMed
  30. J Korean Med Sci. 1998 Feb;13(1):71-6 - PubMed
  31. Pathol Int. 2004 Aug;54(8):611-5 - PubMed
  32. Arch Pathol Lab Med. 1999 Dec;123(12 ):1287-9 - PubMed
  33. J Comput Assist Tomogr. 2004 Jan-Feb;28(1):140-8 - PubMed

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