Display options
Share it on

mSphere. 2016 Feb 17;1(1). doi: 10.1128/mSphere.00016-16. eCollection 2016.

Discovery of a Novel Bat Gammaherpesvirus.

mSphere

Kurtis M Host, Blossom Damania

Affiliations

  1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

PMID: 27303690 PMCID: PMC4863598 DOI: 10.1128/mSphere.00016-16

Abstract

Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first report on a replicating, infectious gammaherpesvirus from bats. The new virus is named bat gammaherpesvirus 8 (BGHV8), also known as Myotis gammaherpesvirus 8, and is able to infect multiple cell lines, including those of human origin. Using next-generation sequencing technology, the authors constructed a full-length annotated genomic map of BGHV8. Phylogenetic analysis of several genes from BGHV8 revealed similarity to several mammalian gammaherpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV).

Keywords: BGHV8; Myotis gammaherpesvirus 8; Myotis velifer incautus; bat; gammaherpesvirus

References

  1. Science. 2000 Jan 28;287(5453):607-14 - PubMed
  2. J Virol. 2000 Apr;74(7):3388-98 - PubMed
  3. Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):535-43 - PubMed
  4. Cytokine Growth Factor Rev. 2001 Jun-Sep;12(2-3):245-57 - PubMed
  5. Philos Trans R Soc Lond B Biol Sci. 2001 Jul 29;356(1411):983-9 - PubMed
  6. J Biol Chem. 2003 Dec 26;278(52):52437-45 - PubMed
  7. Nat Rev Cancer. 2004 Oct;4(10):757-68 - PubMed
  8. Nat Med. 2004 Dec;10(12 Suppl):S88-97 - PubMed
  9. Science. 2005 Oct 28;310(5748):676-9 - PubMed
  10. Nature. 2005 Dec 1;438(7068):575-6 - PubMed
  11. Emerg Infect Dis. 2006 Aug;12(8):1197-202 - PubMed
  12. J Gen Virol. 2007 Oct;88(Pt 10):2651-5 - PubMed
  13. Nature. 2008 Feb 21;451(7181):990-3 - PubMed
  14. Arch Virol. 2009;154(1):171-7 - PubMed
  15. Acta Vet Hung. 2008 Dec;56(4):529-38 - PubMed
  16. Vector Borne Zoonotic Dis. 2009 Dec;9(6):723-8 - PubMed
  17. Virus Genes. 2009 Aug;39(1):90-3 - PubMed
  18. J Clin Invest. 2011 Mar;121(3):1141-53 - PubMed
  19. Vector Borne Zoonotic Dis. 2012 Jan;12(1):65-72 - PubMed
  20. Emerg Infect Dis. 2012 Jan;18(1):83-5 - PubMed
  21. J Virol. 2012 Aug;86(15):8014-30 - PubMed
  22. Science. 2013 Jan 25;339(6118):456-60 - PubMed
  23. Curr Opin Virol. 2013 Feb;3(1):84-91 - PubMed
  24. PLoS Pathog. 2013 Oct;9(10):e1003651 - PubMed
  25. Rev Med Virol. 2014 Jul;24(4):242-53 - PubMed
  26. mSphere. 2016 Feb 17;1(1):null - PubMed
  27. Lancet. 1986 Feb 15;1(8477):378 - PubMed
  28. Science. 1994 Dec 16;266(5192):1865-9 - PubMed
  29. J Biol Chem. 1993 Oct 5;268(28):20691-4 - PubMed

Publication Types