Display options
Cite
Vakil N, Stelwagon M, Shea EP, et al. Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population. United European Gastroenterol J. 2015;4(3):413-22doi: 10.1177/2050640615600114.
Vakil, N., Stelwagon, M., Shea, E. P., & Miller, S. (2016). Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population. United European gastroenterology journal, 4(3), 413-22. https://doi.org/10.1177/2050640615600114
Vakil, Nimish, et al. "Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population." United European gastroenterology journal vol. 4,3 (2016): 413-22. doi: https://doi.org/10.1177/2050640615600114
Vakil N, Stelwagon M, Shea EP, Miller S. Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population. United European Gastroenterol J. 2016 Jun;4(3):413-22. doi: 10.1177/2050640615600114. Epub 2015 Aug 06. PMID: 27403308; PMCID: PMC4924424.
Copy Download .nbib Format: NLM
Share it on

United European Gastroenterol J. 2016 Jun;4(3):413-22. doi: 10.1177/2050640615600114. Epub 2015 Aug 06.

Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population.

United European gastroenterology journal

Nimish Vakil, Margie Stelwagon, Elizabeth P Shea, Steve Miller

Affiliations

  1. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  2. Ironwood Pharmaceuticals, Cambridge MA, USA.
  3. Lieberman Inc, Great Neck, NY, USA.

PMID: 27403308 PMCID: PMC4924424 DOI: 10.1177/2050640615600114

Abstract

BACKGROUND: Regulatory and treatment guidelines focus on individual conditions, yet clinicians often see patients with overlapping conditions.

OBJECTIVE: This cross-sectional survey study assesses the impact of overlapping functional dyspepsia (FD), gastroesophageal reflux disease (GERD), irritable bowel syndrome with constipation (IBS-C), and chronic idiopathic constipation (CIC) on symptom burden and consulting behavior.

METHODS: Survey participants met Rome III criteria for FD, IBS-C, and/or CIC, and/or reported GERD; participants answered questions about symptom frequency and bothersomeness, work and productivity, and consulting behavior.

RESULTS: Of 2641 respondents, 1592 (60.3%) had one condition; 832 (31.5%) had two; and 217 (8.2%) had three; 57.3% of 1690 FD, 54.6% of 1337 GERD, 82.6% of 328 IBS-C, and 62.5% of 552 CIC respondents had condition overlap. Overall GI symptoms were very/extremely bothersome in 28.6% of single-condition respondents, 50.7% of two-condition, and 69.6% of three-condition respondents (p < 0.001, chi square). Symptom frequency and productivity losses both increased with condition overlap. Over 12 months, 43.7% of single-condition, 49.9% of two-condition, and 66.5% of three-condition respondents consulted a physician about GI symptoms (p < 0.001, chi square).

CONCLUSION: Functional GI disorders frequently overlap with each other and with GERD. Condition overlap is associated with greater symptom burden and increased physician consultations.

Keywords: FD; GERD; IBS; IBS-C; Irritable bowel syndrome with constipation; chronic idiopathic constipation; functional dyspepsia; gastroesophageal reflux disease

References

  1. Am J Gastroenterol. 2014 Sep;109(9):1450-60 - PubMed
  2. Am J Gastroenterol. 2008 May;103(5):1229-39; quiz 1240 - PubMed
  3. Aliment Pharmacol Ther. 2000 Dec;14(12):1581-8 - PubMed
  4. Am J Gastroenterol. 2012 Jul;107(7):1011-9 - PubMed
  5. Aliment Pharmacol Ther. 2007 Mar 1;25(5):599-608 - PubMed
  6. Am J Gastroenterol. 2012 Dec;107(12):1793-801; quiz 1802 - PubMed
  7. Gastroenterol Clin North Am. 2010 Sep;39(3):529-42 - PubMed
  8. Am J Gastroenterol. 2014 Jun;109(6):876-84 - PubMed
  9. Scand J Gastroenterol. 2015 Feb;50(2):162-9 - PubMed
  10. Aliment Pharmacol Ther. 2012 Jul;36(1):3-15 - PubMed
  11. Aliment Pharmacol Ther. 2003 Mar 1;17(5):643-50 - PubMed
  12. Am J Gastroenterol. 2010 Oct;105(10):2228-34 - PubMed
  13. Aliment Pharmacol Ther. 2007 Aug 1;26(3):453-61 - PubMed
  14. Am J Gastroenterol. 2006 Aug;101(8):1900-20; quiz 1943 - PubMed
  15. Am J Gastroenterol. 2015 Apr;110(4):580-7 - PubMed
  16. Postgrad Med. 2013 Mar;125(2):40-50 - PubMed
  17. Gastroenterology. 2013 Oct;145(4):749-57; quiz e13-4 - PubMed
  18. World J Gastroenterol. 2006 May 7;12(17):2708-12 - PubMed
  19. J Neurogastroenterol Motil. 2013 Oct;19(4):521-31 - PubMed
  20. Aliment Pharmacol Ther. 2014 Dec;40(11-12):1302-12 - PubMed
  21. Am J Gastroenterol. 2012 Jul;107(7):1001-10 - PubMed
  22. Clin Gastroenterol Hepatol. 2010 May;8(5):401-9 - PubMed
  23. Gastroenterology. 2006 Apr;130(5):1480-91 - PubMed
  24. Am J Gastroenterol. 2014 Aug;109 Suppl 1:S2-26; quiz S27 - PubMed

Publication Types